Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …

Our understanding of pluripotency remains limited: iPSC generation has only been
established for a few model species, pluripotent stem cell lines exhibit inconsistent …

An engineered SOX17 variant with point mutations within its DNA binding domain termed
SOX17FNV is a more potent pluripotency inducer than SOX2, yet the underlying mechanism …

The transcription factor Oct4 is essential for the maintenance and induction of stem cell
pluripotency, but its functional roles are not fully understood. Here, we investigate the …

The support of pluripotent cells over time is an essential feature of development. In eutherian
embryos, pluripotency is maintained from naïve states in peri-implantation to primed …

This review provides a detailed study of pancreatic cancer (PC) and the implication of
different types of cancers concerning diabetes. The combination of anti-diabetic drugs with …

Oct4 is essential to maintain pluripotency and has a pivotal role in establishing the germline.
Its DNA-binding POU domain was recently found to bind motifs with methylated CpG …

During vertebrate development, embryonic cells pass through a continuum of transitory
pluripotent states that precede multi-lineage commitment and morphogenesis. Such states …

The incorporation of bacterial ribosome has been reported to induce multipotency in somatic
and cancer cells which leads to the conversion of cell lineages. Queried on its universality …

Oral squamous cell carcinoma (OSCC), a common malignancy of the head and neck, ranks
sixth worldwide in terms of cancers with the most negative impact, owing to tumor relapse …