Primary cilia are small, antenna-like organelles that detect and transduce chemical and
mechanical cues in the extracellular environment, regulating cell behavior and, in turn …

The intraflagellar transport (IFT) system is a remarkable molecular machine used by cells to
assemble and maintain the cilium, a long organelle extending from eukaryotic cells that …

Cilia sense and transduce extracellular signals via specific receptors. The intraflagellar
transport (IFT) machinery mediates not only bidirectional protein trafficking within cilia but …

Cilia are eukaryotic organelles essential for movement, signaling or sensing. Primary cilia
act as antennae to sense a cell's environment and are involved in a wide range of signaling …

Primary cilia project from the surface of most vertebrate cells and are key in sensing
extracellular signals and locally transducing this information into a cellular response. Recent …

The IFT-B complex mediates ciliary anterograde protein trafficking and membrane protein
export together with the BBSome. Bardet-Biedl syndrome (BBS) is caused by mutations in …

Ciliary receptors and their certain downstream signaling components undergo intraflagellar
transport (IFT) as BBSome cargoes to maintain their ciliary dynamics for sensing and …

Our understanding of motile cilia and their role in disease has increased tremendously over
the last two decades, with critical information and insight coming from the analysis of mouse …

Mutations in SHH and several other genes encoding components of the Hedgehog
signaling pathway have been associated with holoprosencephaly syndromes, with …

The dynein-2 complex must be transported anterogradely within cilia to then drive
retrograde trafficking of the intraflagellar transport (IFT) machinery containing IFT-A and IFT …