Role of epithelial to mesenchymal transition in colorectal cancer

J Lu, M Kornmann, B Traub - International Journal of Molecular Sciences, 2023 - mdpi.com
The epithelial–mesenchymal transition (EMT) is a cellular reprogramming process that
occurs during embryonic development and adult tissue homeostasis. This process involves …

Harnessing minimal residual disease as a predictor for colorectal cancer: Promising horizons amidst challenges

X Wen, D Coradduzza, J Shen, AM Scanu, MR Muroni… - Medicina, 2023 - mdpi.com
Minimal Residual Disease (MRD) detection has emerged as an independent factor in
clinical and pathological cancer assessment offering a highly effective method for predicting …

Plasma cell-free tumor methylome as a biomarker in solid tumors: biology and applications

DB Sacdalan, S Ul Haq, BH Lok - Current Oncology, 2024 - mdpi.com
DNA methylation is a fundamental mechanism of epigenetic control in cells and its
dysregulation is strongly implicated in cancer development. Cancers possess an extensively …

Prospects of liquid biopsy in the prognosis and clinical management of gastrointestinal cancers

D Mondal, S Shinde, V Sinha, V Dixit, S Paul… - Frontiers in Molecular …, 2024 - frontiersin.org
Gastrointestinal (GI) cancers account for one-fourth of the global cancer incidence and are
incriminated to cause one-third of cancer-related deaths. GI cancer includes esophageal …

Measurable residual disease (MRD)-testing in haematological and solid cancers

J Chen, RP Gale, Y Hu, W Yan, T Wang, W Zhang - Leukemia, 2024 - nature.com
There is considerable interest in and enthusiasm for quantitative tests for residual cancer
cells in the context of cancer therapy, a concept referred to as measurable residual disease …

Clinical significance of tumor suppressor genes methylation in circulating tumor DNA of patients with pancreatic cancer

WP Xin, S Tu, S Yi, Y Xiong, K Fang, G Sun, W Xiao - Gene, 2024 - Elsevier
Abstract Background Circulating tumor DNA (ctDNA) has emerged as a potential diagnostic
and prognostic biomarker in various tumors. However, the role of tumor suppressor genes …

Minimal residual disease in solid tumors: an overview

Y Ma, J Gan, Y Bai, D Cao, Y Jiao - Frontiers of Medicine, 2023 - Springer
Minimal residual disease (MRD) is termed as the small numbers of remnant tumor cells in a
subset of patients with tumors. Liquid biopsy is increasingly used for the detection of MRD …

Relationship between MUC4 variants and metastatic recurrence in colorectal cancer

J Liu, R Xing, J Shao, S Jiao - International Journal of General …, 2023 - Taylor & Francis
Background Recurrent metastasis after radical resection in patients of colorectal cancer
(CRC) is a great challenge for the world, in which genomic alterations play a major role in …

Circulating tumour DNA-Based molecular residual disease detection in resectable cancers: a systematic review and meta-analysis

J Zheng, C Qin, Q Wang, D Tian, Z Chen - Ebiomedicine, 2024 - thelancet.com
Summary Background Circulating tumour DNA (ctDNA)-based molecular residual disease
(MRD) detection technology has been widely used for recurrence evaluation, but there is no …

Genome wide-scale CRISPR-Cas9 knockout screens identify a fitness score for optimized risk stratification in colorectal cancer

X Yang, J Liu, S Wang, WHA Al-Ameer, J Ji… - Journal of Translational …, 2024 - Springer
Background The molecular complexity of colorectal cancer poses a significant challenge to
the clinical implementation of accurate risk stratification. There is still an urgent need to find …