Pharmacogenomics of CYP2C9: Functional and Clinical Considerations†
CYP2C9 is the most abundant CYP2C subfamily enzyme in human liver and the most
important contributor from this subfamily to drug metabolism. Polymorphisms resulting in …
important contributor from this subfamily to drug metabolism. Polymorphisms resulting in …
Mechanisms of cytochrome P450-catalyzed oxidations
FP Guengerich - ACS catalysis, 2018 - ACS Publications
Enzymes are complex biological catalysts and are critical to life. Most oxidations of
chemicals are catalyzed by cytochrome P450 (P450, CYP) enzymes, which generally utilize …
chemicals are catalyzed by cytochrome P450 (P450, CYP) enzymes, which generally utilize …
[PDF][PDF] Massively parallel characterization of CYP2C9 variant enzyme activity and abundance
CJ Amorosi, MA Chiasson, MG McDonald… - The American Journal of …, 2021 - cell.com
CYP2C9 encodes a cytochrome P450 enzyme responsible for metabolizing up to 15% of
small molecule drugs, and CYP2C9 variants can alter the safety and efficacy of these …
small molecule drugs, and CYP2C9 variants can alter the safety and efficacy of these …
Four decades of cytochrome P450 2B research: from protein adducts to protein structures and beyond
AG Roberts, JC Stevens, GD Szklarz, EE Scott… - Drug Metabolism and …, 2023 - ASPET
This article features selected findings from the senior author and colleagues dating back to
1978 and covering approximately three-fourths of the 60 years since the discovery of …
1978 and covering approximately three-fourths of the 60 years since the discovery of …
Synthesis, spectral properties, chemical descriptors and light harvesting studies of a new bioactive azo imidazole compound
The manuscript presents the synthesis and detailed spectral calculations of a new
azoimidazole compound 1-[2-(2-hydroxy-3-methoxy-5-phenylazobenzaldeneamino) ethyl]-3 …
azoimidazole compound 1-[2-(2-hydroxy-3-methoxy-5-phenylazobenzaldeneamino) ethyl]-3 …
Machine learning-driven identification of drugs inhibiting cytochrome P450 2C9
Cytochrome P450 2C9 (CYP2C9) is a major drug-metabolizing enzyme that represents 20%
of the hepatic CYPs and is responsible for the metabolism of 15% of drugs. A general …
of the hepatic CYPs and is responsible for the metabolism of 15% of drugs. A general …
Characterization of porcine hepatic and intestinal drug metabolizing CYP450: comparison with human orthologues from a quantitative, activity and selectivity …
W Schelstraete, LD Clerck, E Govaert, J Millecam… - Scientific Reports, 2019 - nature.com
Over the past two decades, the pig has gained attention as a potential model for human drug
metabolism. Cytochrome P450 enzymes (CYP450), a superfamily of biotransformation …
metabolism. Cytochrome P450 enzymes (CYP450), a superfamily of biotransformation …
Metabolites of cannabigerol generated by human cytochrome P450s are bioactive
The phytocannabinoid cannabigerol (CBG) is the central biosynthetic precursor to many
cannabinoids, including Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Though the …
cannabinoids, including Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Though the …
Insights into molecular mechanisms of drug metabolism dysfunction of human CYP2C9* 30
Cytochrome P450 2C9 (CYP2C9) metabolizes about 15% of clinically administrated drugs.
The allelic variant CYP2C9* 30 (A477T) is associated to diminished response to the …
The allelic variant CYP2C9* 30 (A477T) is associated to diminished response to the …
Enzymatic activity of 38 CYP2C9 genotypes on ibuprofen
L Yuan, X Li, F Ye, X Li, Q Li, Y Zhong, S Wang… - Food and Chemical …, 2023 - Elsevier
Background and objective Ibuprofen, a common non-steroidal anti-inflammatory drug, is
used clinically for pain relief and antipyretic treatment worldwide. However, regular or long …
used clinically for pain relief and antipyretic treatment worldwide. However, regular or long …