Fundamental Aspects of Phase-Separated Biomolecular Condensates
Biomolecular condensates, formed through phase separation, are upending our
understanding in much of molecular, cell, and developmental biology. There is an urgent …
understanding in much of molecular, cell, and developmental biology. There is an urgent …
Sequence-dependent material properties of biomolecular condensates and their relation to dilute phase conformations
D Sundaravadivelu Devarajan, J Wang… - Nature …, 2024 - nature.com
Material properties of phase-separated biomolecular condensates, enriched with disordered
proteins, dictate many cellular functions. Contrary to the progress made in understanding the …
proteins, dictate many cellular functions. Contrary to the progress made in understanding the …
[HTML][HTML] Sequence-dependent material properties of biomolecular condensates and their relation to dilute phase conformations
DS Devarajan, J Wang, B Szała-Mendyk… - Nature …, 2024 - ncbi.nlm.nih.gov
Material properties of phase-separated biomolecular condensates, enriched with disordered
proteins, dictate many cellular functions. Contrary to the progress made in understanding the …
proteins, dictate many cellular functions. Contrary to the progress made in understanding the …
Protamine-Mediated Tangles Produce Extreme Deoxyribonucleic Acid Compaction
V Ahlawat, A Dhiman, HE Mudiyanselage… - Journal of the …, 2024 - ACS Publications
In sperm cells, protamine replaces histones to compact DNA 10–20 times more than in
somatic cells. To characterize the extreme compaction, we employed confocal microscopy …
somatic cells. To characterize the extreme compaction, we employed confocal microscopy …
[HTML][HTML] The mitochondria chronicles of melatonin and ATP: Guardians of phase separation
Phase separation is a thermodynamic process used by all living organisms since the origin
of life to rapidly assemble and disassemble membraneless condensates in response to …
of life to rapidly assemble and disassemble membraneless condensates in response to …
[HTML][HTML] Amino acid-dependent phase equilibrium and material properties of tetrapeptide condensates
The rules of how amino acids dictate the physical properties of biomolecular condensates
are still incomplete. Here, we study condensates formed by tetrapeptides of the form …
are still incomplete. Here, we study condensates formed by tetrapeptides of the form …
Direct and indirect salt effects on homotypic phase separation
The low-complexity domain of hnRNPA1 (A1-LCD) phase separates in a salt-dependent
manner. Unlike many intrinsically disordered proteins (IDPs) whose phase separation is …
manner. Unlike many intrinsically disordered proteins (IDPs) whose phase separation is …
Reentrant Condensation of Polyelectrolytes Induced by Diluted Multivalent Salts: The Role of Electrostatic Gluonic Effects
H Yong - Biomacromolecules, 2024 - ACS Publications
We explore the reentrant condensation of polyelectrolytes triggered by multivalent salts,
whose phase-transition mechanism remains under debate. We propose a theory to study the …
whose phase-transition mechanism remains under debate. We propose a theory to study the …
[HTML][HTML] Amino Acid-Dependent Material Properties of Tetrapeptide Condensates
Condensates formed by intrinsically disordered proteins mediate a myriad of cellular
processes and are linked to pathological conditions including neurodegeneration. Rules of …
processes and are linked to pathological conditions including neurodegeneration. Rules of …
ATP promotes protein coacervation through conformational compaction
Y Zhu, S Lin, L Meng, M Sun, M Liu, J Li… - Journal of Molecular …, 2024 - academic.oup.com
ATP has been recognized as a hydrotrope in the phase separation process of intrinsically
disordered proteins (IDPs). Surprisingly, when using the disordered RG/RGG-rich motif from …
disordered proteins (IDPs). Surprisingly, when using the disordered RG/RGG-rich motif from …