Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

Abundant filamentous inclusions of tau are characteristic of more than 20
neurodegenerative diseases that are collectively termed tauopathies. Electron cryo …

Intermediate species in the assembly of amyloid filaments are believed to play a central role
in neurodegenerative diseases and may constitute important targets for therapeutic …

Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …

The protein Tau aggregates into tangles in the brain of patients with Alzheimer's disease. In
solution, however, Tau is intrinsically disordered, highly soluble, and binds to microtubules …

Assembly of microtubule-associated protein tau into filamentous inclusions underlies a
range of neurodegenerative diseases. Tau filaments adopt different conformations in …

Alzheimer's disease (AD) is characterized by two major pathological lesions in the brain,
amyloid plaques and neurofibrillary tangles (NFTs) composed mainly of amyloid-β (Aβ) …

Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …

Tau represents the subunit protein of one of the major hallmarks of Alzheimer disease (AD),
the neurofibrillary tangles, and is therefore of major interest as an indicator of disease …