Hot-melt extrusion (HME) has emerged as a pioneering manufacturing technology for
pharmaceutical industries, and the utilization is overgrowing due to its unit operation, cost …

Industrial-scale pharmaceutical applications still face many challenges in overcoming the
low absorption and bioavailability of poorly water-soluble drugs. Hot-melt extrusion has …

Abstract Three-dimensional (3D) printing allows for the design and printing of more complex
designs than traditional manufacturing processes. For the manufacture of personalised …

The complexation of cyclodextrin ranks among the best methods of overcoming the
unfavorable pharmacokinetic properties of naringenin (NAR). This work proposes obtaining …

In this study, the amorphous solid dispersions of cyclosporine A (CsA-ASDs) were prepared
by hot melt extrusion (HME) with PVP K12 as carrier to improve the oral bioavailability of …

Hot melt extrusion (HME) is a technique applied in the preparation of pharmaceutical
amorphous solid dispersions (ASD). Notably it is important to prevent thermal degradation of …

Hot-melt extrusion is often used to prepare amorphous solid dispersion to overcome low
drug solubility and enhance bio-performance of the formulation. Due to the uniqueness of …

Novel high drug loading amorphous solid dispersions (HDASDs) based on the in situ
thermal crosslinked polymeric carriers/matrices have been recently introduced as an …

Introduction Amorphous solid dispersion (ASD) technique has recently been used as an
effective formulation strategy to significantly improve the bioavailability of insoluble drugs …

This paper aims to give an overview of our current research and development on hot‐melt
extrusion (HME) for pharmaceutical formulation and drug delivery. Unfortunately, a large …