Lipid-based nanoparticles for delivery of vaccine adjuvants and antigens: toward multicomponent vaccines

D Chatzikleanthous, DT O'Hagan… - Molecular …, 2021 - ACS Publications
Despite the many advances that have occurred in the field of vaccine adjuvants, there are
still unmet needs that may enable the development of vaccines suitable for more …

Liposomes used as a vaccine adjuvant-delivery system: From basics to clinical immunization

N Wang, M Chen, T Wang - Journal of Controlled Release, 2019 - Elsevier
Liposomes are widely utilized as a carrier to improve therapeutic efficacy of agents thanks to
their merits of high loading capacity, targeting delivery, reliable protection of agents, good …

Liposome and immune system interplay: Challenges and potentials

F Zahednezhad, M Saadat, H Valizadeh… - Journal of Controlled …, 2019 - Elsevier
Liposome as a revolutionizing carrier, has exhibited favorable aspects in drug delivery.
However, there are numerous challenges affecting its effectiveness. Hypersensitivity …

Recent advances in intranasal liposomes for drug, gene, and vaccine delivery

VA Duong, TTL Nguyen, HJ Maeng - Pharmaceutics, 2023 - mdpi.com
Liposomes are safe, biocompatible, and biodegradable spherical nanosized vesicles
produced from cholesterol and phospholipids. Recently, liposomes have been widely …

Vaccine approaches for antigen capture by liposomes

S Zhou, Y Luo, JF Lovell - Expert Review of Vaccines, 2023 - Taylor & Francis
Introduction Liposomes have been used as carriers for vaccine adjuvants and antigens due
to their inherent biocompatibility and versatility as delivery vehicles. Two vial admixture of …

The role of mucoadhesion and mucopenetration in the immune response induced by polymer-based mucosal adjuvants

N Vasquez-Martínez, D Guillen, SA Moreno-Mendieta… - Polymers, 2023 - mdpi.com
Mucus is a viscoelastic gel that acts as a protective barrier for epithelial surfaces. The
mucosal vehicles and adjuvants need to pass through the mucus layer to make drugs and …

Long-term generation of antiPCSK9 antibody using a nanoliposome-based vaccine delivery system

AA Momtazi-Borojeni, MR Jaafari, A Badiee… - Atherosclerosis, 2019 - Elsevier
Background and aims Proprotein convertase subtilisin kexin type 9 (PCSK9) is a liver
secretory enzyme that controls plasma low-density lipoprotein cholesterol (LDL-C) levels …

Developing oral nanovaccines for fish: A modern trend to fight infectious diseases

C Angulo, M Tello‐Olea, M Reyes‐Becerril… - Reviews in …, 2021 - Wiley Online Library
Nanovaccines constitute an innovative approach in vaccinology, enabled by the
nanotechnology advances on the synthesis, functionalization and application of …

Development of COVID-19 vaccine using a dual Toll-like receptor ligand liposome adjuvant

MM Abhyankar, BJ Mann, JM Sturek, S Brovero… - npj Vaccines, 2021 - nature.com
We developed a SARS-CoV-2 spike subunit vaccine formulation containing dual TLR ligand
liposome adjuvant. The vaccine-induced robust systemic neutralizing antibodies and …

Co-encapsulation of synthetic lipidated TLR4 and TLR7/8 agonists in the liposomal bilayer results in a rapid, synergistic enhancement of vaccine-mediated humoral …

KK Short, SM Miller, L Walsh, V Cybulski… - Journal of Controlled …, 2019 - Elsevier
To increase vaccine immunogenicity, modern vaccines incorporate adjuvants, which serve
to enhance immune cross-protection, improve humoral and cell-mediated immunity, and …