Different neuroplastic processes can occur along the nociceptive pathways and may be
important in the transition from acute to chronic pain and for diagnosis and development of …

Studies have suggested that quantitative sensory testing (QST) might hold a predictive value
for the development of chronic postoperative pain and the response to pharmacological …

Objective Pain sensitization is associated with pain severity in knee osteoarthritis (OA), but
its cause in humans is not well understood. We examined whether inflammation, assessed …

Background Knee osteoarthritis (OA) is among the most common and disabling persistent
pain conditions, with increasing prevalence and impact around the globe. In the US, the …

Musculoskeletal pain disorders are the second largest contributor to global disability
underlining the significance of effective treatments. However, treating chronic …

Chronic postoperative pain after total knee replacement (TKR) in knee osteoarthritis (KOA)
implies clinical challenges. Widespread hyperalgesia, facilitated temporal summation of …

Treating chronic musculoskeletal pain, and chronic joint pain (osteoarthritis (OA)) in
particular, is challenging as the peripheral and central pain mechanisms are not fully …

Valid and reliable biomarkers can play an important role in clinical trials as indicators of
biological or pathogenic processes or as a signal of treatment response. Currently, there are …

Conditioned pain modulation (CPM) is a promising psychophysical biomarker of central pain
mechanisms because it significantly discriminates patients with chronic pain from healthy …

Preoperative pain characteristics in patients with osteoarthritis may explain persistent pain
after total knee replacement. Fifty patients awaiting total knee replacement and 22 …