Pioneer factors are transcription factors with the unique ability to initiate opening of closed
chromatin. The stability of cell identity relies on robust mechanisms that maintain the …

The increasingly recognized role of different types of B cells and plasma cells in protective
and pathogenic immune responses combined with technological advances have generated …

This protocol explains how to perform a fast SCENIC analysis alongside standard best
practices steps on single-cell RNA-sequencing data using software containers and Nextflow …

Recent evidence has elucidated how multipotent blood progenitors transform their identities
in the thymus and undergo commitment to become T cells. Together with environmental …

There is considerable evidence that chromosome structure plays important roles in gene
control, but we have limited understanding of the proteins that contribute to structural …

Immune tolerance hinders the potentially destructive responses of lymphocytes to host
tissues. Tolerance is regulated at the stage of immature B cell development (central …

MicroRNAs (miRNAs) are crucial post-transcriptional regulators of haematopoietic cell fate
decisions. They act by negatively regulating the expression of key immune development …

Summary Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and
recruit Mediator to activate much of the gene expression program of pluripotent embryonic …

Adoptive immunotherapy using chimeric antigen receptor (CAR) expressing T cells targeting
the CD19 B lineage receptor has demonstrated marked success in relapsed pre-B-cell acute …

Developmental progression is driven by specific spatiotemporal domains of gene
expression, which give rise to stereotypically patterned embryos even in the presence of …