Immune responses to Neisseria gonorrhoeae and implications for vaccine development

T Belcher, CS Rollier, C Dold, JDC Ross… - Frontiers in …, 2023 - frontiersin.org
Neisseria gonorrheoae is the causative agent of gonorrhea, a sexually transmitted infection
responsible for a major burden of disease with a high global prevalence. Protective …

Mechanisms of host manipulation by Neisseria gonorrhoeae

E Walker, S van Niekerk, K Hanning, W Kelton… - Frontiers in …, 2023 - frontiersin.org
Neisseria gonorrhoeae (also known as gonococcus) has been causing gonorrhoea in
humans since ancient Egyptian times. Today, global gonorrhoea infections are rising at an …

Progress toward a gonococcal vaccine: the way forward

MW Russell, AE Jerse, SD Gray-Owen - Frontiers in immunology, 2019 - frontiersin.org
The concept of immunizing against gonorrhea has received renewed interest because of the
recent emergence of strains of Neisseria gonorrhoeae that are resistant to most currently …

CEACAM1 as a multi-purpose target for cancer immunotherapy

M Dankner, SD Gray-Owen, YH Huang… - …, 2017 - Taylor & Francis
ABSTRACT CEACAM1 is an extensively studied cell surface molecule with established
functions in multiple cancer types, as well as in various compartments of the immune system …

CEACAM1 structure and function in immunity and its therapeutic implications

WM Kim, YH Huang, A Gandhi, RS Blumberg - Seminars in immunology, 2019 - Elsevier
The type I membrane protein receptor carcinoembryonic antigen-related cell adhesion
molecule 1 (CEACAM1) distinctively exhibits significant alternative splicing that allows for …

Pathogenesis of Neisseria gonorrhoeae in the female reproductive tract: neutrophilic host response, sustained infection, and clinical sequelae

JS Stevens, AK Criss - Current opinion in hematology, 2018 - journals.lww.com
Pathogenesis of Neisseria gonorrhoeae in the female reproduc... : Current Opinion in
Hematology Pathogenesis of Neisseria gonorrhoeae in the female reproductive tract …

Dual species transcriptomics reveals conserved metabolic and immunologic processes in interactions between human neutrophils and Neisseria gonorrhoeae

AD Potter, VL Edwards, A D'Mello, MC Gray… - PLoS …, 2024 - journals.plos.org
Neisseria gonorrhoeae (the gonococcus, Gc) causes the sexually transmitted infection
gonorrhea. Gc is a prominent threat to human health by causing severe lifelong sequelae …

Variable expression of opa proteins by Neisseria gonorrhoeae influences bacterial association and phagocytic killing by human neutrophils

AM Alcott, LM Werner, CM Baiocco… - Journal of …, 2022 - Am Soc Microbiol
Neisseria gonorrhoeae infection is characterized by local and abundant recruitment of
neutrophils. Despite neutrophils' antimicrobial activities, viable N. gonorrhoeae is recovered …

Gonococcal defenses against antimicrobial activities of neutrophils

A Palmer, AK Criss - Trends in microbiology, 2018 - cell.com
Neisseria gonorrhoeae initiates a strong local immune response that is characterized by
copious recruitment of neutrophils to the site of infection. Neutrophils neutralize microbes by …

Characterization of outer membrane vesicles released by clinical isolates of Neisseria gonorrhoeae

S Dhital, P Deo, I Stuart, C Huang, L Zavan… - …, 2024 - Wiley Online Library
The sexually transmitted pathogen Neisseria gonorrhoeae releases membrane vesicles
including outer membrane vesicles (OMVs) during infections. OMVs traffic outer membrane …