For more than 40 years, the epipodophyllotoxin drug etoposide is prescribed to treat cancer.
This semi-synthetic compound remains extensively used to treat advanced small-cell lung …

Simple Summary Although rare, hemophagocytic lymphohistiocytosis (HLH), a syndrome of
severe, dysregulated inflammation, is associated with poor survival when it occurs in …

Background: Acquired hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially
fatal condition characterized by hyperactivation of macrophages and cytotoxic lymphocytes …

Background Programmed cell death protein 1 (PD-1) checkpoint inhibitors such as
pembrolizumab are novel therapeutics used to treat various advanced malignancies …

As indications for immune checkpoint inhibitors for breast cancer continue to expand, rare
toxicities will emerge that require careful consideration and multidisciplinary management …

Treatment with immune checkpoint inhibitors (ICI) such as carrizumab leads to immune‐
mediated adverse effects including severe acute graft versus host disease (aGVHD) and …

Clinical Practice Points• As there are increasingly more indications for immune checkpoint
inhibitors (ICI), immune related adverse events will also become more prevalent. ICI induced …

Hemophagocytic lymphohistiocytosis (HLH) is a potentially life-threatening condition
characterized by dysregulation of the immune system leading to overproduction of …

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of severe, dysregulated
inflammation driven by the inability of T cells to clear an antigenic target. When associated …