Epigenetics as a mediator of plasticity in cancer
AP Feinberg, A Levchenko - Science, 2023 - science.org
The concept of an epigenetic landscape describing potential cellular fates arising from
pluripotent cells, first advanced by Conrad Waddington, has evolved in light of experiments …
pluripotent cells, first advanced by Conrad Waddington, has evolved in light of experiments …
Breast cancer heterogeneity and its implication in personalized precision therapy
L Guo, D Kong, J Liu, L Zhan, L Luo, W Zheng… - … hematology & oncology, 2023 - Springer
Breast cancer heterogeneity determines cancer progression, treatment effects, and
prognosis. However, the precise mechanism for this heterogeneity remains unknown owing …
prognosis. However, the precise mechanism for this heterogeneity remains unknown owing …
Multiomic analysis of malignant pleural mesothelioma identifies molecular axes and specialized tumor profiles driving intertumor heterogeneity
Malignant pleural mesothelioma (MPM) is an aggressive cancer with rising incidence and
challenging clinical management. Through a large series of whole-genome sequencing …
challenging clinical management. Through a large series of whole-genome sequencing …
Tissue biology: in search of a new paradigm
Animal tissues are made up of multiple cell types that are increasingly well-characterized,
yet our understanding of the core principles that govern tissue organization is still …
yet our understanding of the core principles that govern tissue organization is still …
Tumour heterogeneity and the evolutionary trade-offs of cancer
Tumours vary in gene expression programmes and genetic alterations. Understanding this
diversity and its biological meaning requires a theoretical framework, which could in turn …
diversity and its biological meaning requires a theoretical framework, which could in turn …
Archetype tasks link intratumoral heterogeneity to plasticity and cancer hallmarks in small cell lung cancer
Small cell lung cancer (SCLC) tumors comprise heterogeneous mixtures of cell states,
categorized into neuroendocrine (NE) and non-neuroendocrine (non-NE) transcriptional …
categorized into neuroendocrine (NE) and non-neuroendocrine (non-NE) transcriptional …
CCT3-LINC00326 axis regulates hepatocarcinogenic lipid metabolism
JN Søndergaard, C Sommerauer, I Atanasoai, LC Hinte… - Gut, 2022 - gut.bmj.com
Objective To better comprehend transcriptional phenotypes of cancer cells, we globally
characterised RNA-binding proteins (RBPs) to identify altered RNAs, including long non …
characterised RNA-binding proteins (RBPs) to identify altered RNAs, including long non …
Emergence of division of labor in tissues through cell interactions and spatial cues
Most cell types in multicellular organisms can perform multiple functions. However, not all
functions can be optimally performed simultaneously by the same cells. Functions …
functions can be optimally performed simultaneously by the same cells. Functions …
Sex-dependent control of pheromones on social organization within groups of wild house mice
N Zilkha, SG Chuartzman, Y Sofer, Y Pen, M Cum… - Current biology, 2023 - cell.com
Dominance hierarchy is a fundamental social phenomenon in a wide range of mammalian
species, critically affecting fitness and health. Here, we investigate the role of pheromone …
species, critically affecting fitness and health. Here, we investigate the role of pheromone …
The paradox of cooperation among selfish cancer cells
It is traditionally assumed that during cancer development, tumor cells abort their initially
cooperative behavior (ie, cheat) in favor of evolutionary strategies designed solely to …
cooperative behavior (ie, cheat) in favor of evolutionary strategies designed solely to …