The concept of an epigenetic landscape describing potential cellular fates arising from
pluripotent cells, first advanced by Conrad Waddington, has evolved in light of experiments …

Breast cancer heterogeneity determines cancer progression, treatment effects, and
prognosis. However, the precise mechanism for this heterogeneity remains unknown owing …

Malignant pleural mesothelioma (MPM) is an aggressive cancer with rising incidence and
challenging clinical management. Through a large series of whole-genome sequencing …

Animal tissues are made up of multiple cell types that are increasingly well-characterized,
yet our understanding of the core principles that govern tissue organization is still …

Tumours vary in gene expression programmes and genetic alterations. Understanding this
diversity and its biological meaning requires a theoretical framework, which could in turn …

Small cell lung cancer (SCLC) tumors comprise heterogeneous mixtures of cell states,
categorized into neuroendocrine (NE) and non-neuroendocrine (non-NE) transcriptional …

Objective To better comprehend transcriptional phenotypes of cancer cells, we globally
characterised RNA-binding proteins (RBPs) to identify altered RNAs, including long non …

Most cell types in multicellular organisms can perform multiple functions. However, not all
functions can be optimally performed simultaneously by the same cells. Functions …

Dominance hierarchy is a fundamental social phenomenon in a wide range of mammalian
species, critically affecting fitness and health. Here, we investigate the role of pheromone …

It is traditionally assumed that during cancer development, tumor cells abort their initially
cooperative behavior (ie, cheat) in favor of evolutionary strategies designed solely to …