Histone lysine specific demethylase 1 (LSD1) was reported to be overexpressed in several
human cancers and recognized as a promising anticancer drug target. In the current study …

The protein kinase R (PKR, also called EIF2AK2) is an interferon-inducible double-stranded
RNA protein kinase with multiple effects on cells that plays an active part in the cellular …

Seven-membered heterocyclic compounds are important drug scaffolds because of their
unique chemical structures. They widely exist in natural products and show a variety of …

Abstract A series of novel 1, 2, 3-triazole-pyrimidine hybrids were designed, synthesized and
evaluated for their anticancer activity against four selected cancer cell lines (MGC-803, EC …

Abstract A series of novel 1, 2, 3-triazole–pyrimidine–urea hybrids were designed,
synthesized and evaluated for anticancer activity against four selected cancer cell lines …

Abstracts This work used quantum chemical method via DFT to calculate molecular
descriptors for the development of QSAR model to predict bioactivity (IC 50-50% inhibition …

In the search for new biologically active molecules, diversity-oriented synthetic strategies
break through the limitation of traditional library synthesis by sampling new chemical space …

Herein, we present a highly enantioselective desymmetrization of 3-substituted oxetanes
enabled by a confined chiral phosphoric acid. This metal-free process allows effective …

A series of benzenesulfonamide derivatives were synthesized and evaluated for their anti-
proliferative activity and interaction with tubulin. These new derivatives showed significant …

Purine bases have attracted much attention due to their potential biological activities.
Developing more efficient methods for the modification of purine bases with a substitution …