The cerebellum is a brain structure that is highly interconnected with other brain regions.
There are many contributing factors to cerebellar-related brain disease, such as altered …

The effective therapeutic treatment and the disease-modifying therapy for spinocerebellar
ataxia type 2 (SCA2)(a progressive hereditary disease caused by an expansion of …

Multiple sclerosis is a leading cause of neurological disability in adults. Heterogeneity in
multiple sclerosis clinical presentation has posed a major challenge for identifying genetic …

Vogt–Koyanagi–Harada (VKH) disease is a systemic autoimmune disorder affecting multiple
organs, including eyes, skin, and central nervous system. It is known that monocytes …

Spinocerebellar ataxias (SCAs) are a group of hereditary neurodegenerative diseases
mostly affecting cerebellar Purkinje cells caused by a wide variety of different mutations. One …

A CAG repeat sequence in the ATXN2 gene encodes a polyglutamine (polyQ) tract within
the ataxin-2 (ATXN2) protein, showcasing a complex landscape of functions that have been …

Within the cerebellar cortex, mossy fibers (MFs) excite granule cells (GCs) that excite
Purkinje cells (PCs), which provide outputs to the deep cerebellar nuclei (DCNs). It is well …

Adipogenesis is a finely controlled process and its dysfunction may contribute to metabolic
disorders such as obesity. Metastasis suppressor 1 (MTSS1) is a player in tumorigenesis …

Background The welding process releases potentially hazardous gases and fumes, mainly
composed of metallic oxides, fluorides and silicates. Long term welding fume (WF) …

Abstract Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominantly inherited
neurodegenerative disease caused by CAG repeat expansion in the first coding exon of the …