The mitochondrial permeability transition (PT) is a permeability increase of the inner
mitochondrial membrane mediated by a channel, the permeability transition pore (PTP) …

The assembly of the NLRP3 inflammasome can promote the release of IL-1β/IL-18 and
initiate pyroptosis. Accordingly, the dysregulation of NLRP3 inflammasome activation is …

Extensively revised, the fourth edition of this highly successful book takes into account the
many newly determined protein structures that provide molecular insight into chemiosmotic …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Loss of mitochondrial membrane potential (ΔΨm) triggers dramatic structural changes in
mitochondria from a tubular to globular shape, referred to as mitochondrial fragmentation; …

The NLRP3 inflammasome is a cytosolic complex that activates Caspase-1, leading to
maturation of interleukin-1β (IL-1β) and IL-18 and induction of proinflammatory cell death in …

Cancer chemotherapeutics like paclitaxel and oxaliplatin produce a dose-limiting chronic
sensory peripheral neuropathy that is often accompanied by neuropathic pain. The cause of …

Significance: In addition to their classical role in cellular ATP production, mitochondria are of
key relevance in various (patho) physiological mechanisms including second messenger …

Mitochondria are critical players involved in both cell life and death through multiple
pathways. Structural integrity, metabolism and function of mitochondria are regulated by …

Ever increasing environmental presence of cadmium as a consequence of industrial
activities is considered a health hazard and is closely linked to deteriorating global health …