Glioblastomas are heterogeneous and invariably lethal tumours. They are characterized by
genetic and epigenetic variations among tumour cells, which makes the development of …

Glioblastoma is one of the most lethal human cancers, with poor survival despite surgery,
radiation treatment, and chemotherapy. Advances in the treatment of this type of brain tumor …

Drug repositioning refers to the concept of discovering novel clinical benefits of drugs that
are already known for use treating other diseases. The advantages of this are that several …

Malignant gliomas are relentless tumors that offer a dismal clinical prognosis. They develop
many biological advantages that allow them to grow and survive in the unique environment …

Protein kinase C (PKC) is a family of phospholipid‐dependent serine/threonine kinases,
which can be further classified into three PKC isozymes subfamilies: conventional or classic …

Astrocytes are critical for the development and function of synapses. There are notable
species differences between human astrocytes and commonly used animal models. Yet, it is …

In the modern era, cancer can be controlled by chemotherapy treatment, and in many
situations a stable disease is obtained. The significant clinical success and subsequent …

Abstract l-Glutamate is the predominant excitatory neurotransmitter in the central nervous
system (CNS) and is directly and indirectly involved in a variety of brain functions. Glutamate …

Glioblastoma is an aggressive tumor and is associated with a dismal prognosis. The
availability of few active treatments as well as the inexorable recurrence after surgery are …

Highlights•SLCs play a key part in the metabolically driven tumor growth and
metastasis.•SLCs can exert both tumor-promoting as well as suppressive functions in …