Approximately 40% of new chemical entities (NCEs), including anticancer drugs, have been
reported as poorly water-soluble compounds. Anticancer drugs are classified into biologic …

Many new chemical entities (NCEs) have been discovered with the development of the
pharmaceutical industry. However, the main disadvantage of these drugs is their low …

Background The purpose of this study was to screen various drug delivery systems for
improving the aqueous solubility and oral bioavailability of sildenafil. Three representative …

The particle aggregation of β-carotene has been a challenge for the development of
powdery microcapsules with a high loading. Herein, solvent-free β-carotene high loaded …

Solubility limited bioavailability is one of the crucial parameters that affect the formulation
development of the new chemical entities. Thus the major constraint in the pharmaceutical …

In this study, a solidified self-nanoemulsifying drug delivery system (solidified SNEDDS) and
surface-modified microspheres were developed for enhancing the oral bioavailability of …

In this study, novel ritonavir solid dispersion (RTV SD) formulations were prepared with
copovidone (PVPVA 64) and optimized plasticizers via hot-melt extrusion (HME) at different …

Although solid dispersions have been reported as an efficient drug delivery system, the
design of specific dosage forms for pharmaceutical therapy is necessary to improve the …

This study aimed to compare high-pressure homogenization (HPH) and Shirasu porous
glass (SPG) membrane emulsification for enhancing the oral bioavailability of rivaroxaban …

Kaempferol (KPF), an important flavonoid, has been reported to exert antioxidant, anti-
inflammatory, and anticancer activity. However, this compound has low water solubility and …