Structural and biophysical mechanisms of class CG protein-coupled receptor function
A Ellaithy, J Gonzalez-Maeso, DA Logothetis… - Trends in biochemical …, 2020 - cell.com
Groundbreaking structural and spectroscopic studies of class AG protein-coupled receptors
(GPCRs), such as rhodopsin and the β 2 adrenergic receptor, have provided a picture of …
(GPCRs), such as rhodopsin and the β 2 adrenergic receptor, have provided a picture of …
[HTML][HTML] G protein-coupled receptor-effector macromolecular membrane assemblies (GEMMAs)
G protein-coupled receptors (GPCRs) are the largest group of receptors involved in cellular
signaling across the plasma membrane and a major class of drug targets. The canonical …
signaling across the plasma membrane and a major class of drug targets. The canonical …
[HTML][HTML] Chemerin forms: their generation and activity
Chemerin is the product of the RARRES2 gene which is secreted as a precursor of 143
amino acids. That precursor is inactive, but proteases from the coagulation and fibrinolytic …
amino acids. That precursor is inactive, but proteases from the coagulation and fibrinolytic …
[HTML][HTML] Structure-function relationships of the follicle-stimulating hormone receptor
The follicle-stimulating hormone receptor (FSHR) plays a crucial role in reproduction. This
structurally complex receptor is a member of the G-protein coupled receptor (GPCR) …
structurally complex receptor is a member of the G-protein coupled receptor (GPCR) …
[HTML][HTML] Angiotensin receptors heterodimerization and trafficking: how much do they influence their biological function?
NL Rukavina Mikusic, MG Silva, AM Pineda… - Frontiers in …, 2020 - frontiersin.org
G-protein–coupled receptors (GPCRs) are targets for around one third of currently approved
and clinical prescribed drugs and represent the largest and most structurally diverse family …
and clinical prescribed drugs and represent the largest and most structurally diverse family …
The M1 muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes
S Marsango, L Jenkins, JD Pediani… - Proceedings of the …, 2022 - National Acad Sciences
The quaternary organization of rhodopsin-like G protein-coupled receptors in native tissues
is unknown. To address this we generated mice in which the M1 muscarinic acetylcholine …
is unknown. To address this we generated mice in which the M1 muscarinic acetylcholine …
[HTML][HTML] Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor
Metabotropic glutamate receptors (mGluRs) are class C, synaptic G-protein-coupled
receptors (GPCRs) that contain large extracellular ligand binding domains (LBDs) and form …
receptors (GPCRs) that contain large extracellular ligand binding domains (LBDs) and form …
[HTML][HTML] Interrogating surface versus intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates
Employing self-labelling protein tags for the attachment of fluorescent dyes has become a
routine and powerful technique in optical microscopy to visualize and track fused proteins …
routine and powerful technique in optical microscopy to visualize and track fused proteins …
ACE2 internalization induced by a SARS-CoV-2 recombinant protein is modulated by angiotensin II type 1 and bradykinin 2 receptors
Aims Angiotensin-converting enzyme 2 (ACE2) is a key regulator of the renin-angiotensin
system (RAS) recently identified as the membrane receptor for the severe acute respiratory …
system (RAS) recently identified as the membrane receptor for the severe acute respiratory …
The function and allosteric control of the human sweet taste receptor
G Servant, T Kenakin, L Zhang, M Williams… - Advances in …, 2020 - Elsevier
Humans perceive sweet taste via activation of a specific taste receptor expressed at the
surface of taste receptor cells located on the tongue and soft palate papillae. The sweet taste …
surface of taste receptor cells located on the tongue and soft palate papillae. The sweet taste …