Ca2+-stimulated adenylyl cyclases as therapeutic targets for psychiatric and neurodevelopmental disorders

J Chen, Q Ding, L An, H Wang - Frontiers in Pharmacology, 2022 - frontiersin.org
As the main secondary messengers, cyclic AMP (cAMP) and Ca2+ trigger intracellular signal
transduction cascade and, in turn, regulate many aspects of cellular function in developing …

Meiotic divisions: no place for gender equality

W El Yakoubi, K Wassmann - Cell Division Machinery and Disease, 2017 - Springer
In multicellular organisms the fusion of two gametes with a haploid set of chromosomes
leads to the formation of the zygote, the first cell of the embryo. Accurate execution of the …

IDDB: a comprehensive resource featuring genes, variants and characteristics associated with infertility

J Wu, D Li, X Liu, Q Li, X He, J Wei, X Li… - Nucleic Acids …, 2021 - academic.oup.com
Infertility is a complex multifactorial disease that affects up to 10% of couples across the
world. However, many mechanisms of infertility remain unclear due to the lack of studies …

Functional analysis of schizophrenia genes using GeneAnalytics program and integrated databases

T Sundararajan, AM Manzardo, MG Butler - Gene, 2018 - Elsevier
Schizophrenia (SCZ) is a chronic debilitating neuropsychiatric disorder with multiple risk
factors involving numerous complex genetic influences. We examined and updated a master …

MicroRNA-targeting in male infertility: Sperm microRNA-19a/b-3p and its spermatogenesis related transcripts content in men with oligoasthenozoospermia

M Abu-Halima, LS Becker, BM Ayesh… - Frontiers in Cell and …, 2022 - frontiersin.org
Objective: To elucidate and validate the potential regulatory function of miR-19a/b-3p and its
spermatogenesis-related transcripts content in sperm samples collected from men with …

Needs and wants in mosque architecture: a study of traditional and modern mosques in West Java-Indonesia

IA Wirakusumah, A Antariksa, P Salura - Linguistics and Culture Review, 2021 - lingcure.org
Generally, the study on mosque architecture focuses partly on classifying mosque forms or
exploring the historical, socio-cultural, and political meanings behind the architectural …

Sex differences in obesity-induced inflammation

S Terrazas, L Brashear, AK Escoto… - Translational Studies …, 2019 - books.google.com
Obesity is defined as a BMI greater than 25 kg/m2. Once thought to simply be a nutritional
disorder, obesity has become a major health concern characterized by a state of constant …

Exploring genetic susceptibility to obesity through genome functional pathway analysis

AP Gabrielli, AM Manzardo, MG Butler - Obesity, 2017 - Wiley Online Library
Objective Obesity has been reaching epidemic levels in recent decades, with a growing
body of research identifying predisposing genetic components. To explore the relationship …

Inferring Gene Regulatory Networks of Als from Blood Transcriptome Profiles

XG Pappalardo, G Jansen, M Amaradio… - Available at SSRN … - papers.ssrn.com
One of the most robust approaches to the prediction of causal driver genes of complex
diseases is to apply reverse engineering methods to infer a gene regulatory network (GRN) …

İnfertilite tanısı alan çiftlerde polimorfik varyant kabul edilen kromozom değişikliklerinin değerlendirilmesi

YM Şener - 2022 - acikerisim.aku.edu.tr
İnfertilite, kişinin üreme kapasitesinin bozulması olarak tanımlanan bir hastalıktır.
İnfertilitenin patogenezinde genetik faktörlerin etkisi olduğu bilinmektedir. Bu noktada …