Streptomycetes are the most abundant source of antibiotics. Typically, each species
produces several antibiotics, with the profile being species specific. Streptomyces coelicolor …

Actinomycetes are a rich source of natural products, and these mycelial bacteria produce the
majority of the known antibiotics. The increasing difficulty to find new drugs via high …

Bacteria of the Streptomyces genus constitute an authentic biotech gold mine thanks to their
ability to produce a myriad of compounds and enzymes of great interest at various clinical …

Streptomyces, the main antibiotic-producing bacteria, responds to changing environmental
conditions through a complex sensing mechanism and two-component systems (TCSs) play …

Soil dwelling Streptomyces species are faced with large variations in carbon or nitrogen
sources, phosphate, oxygen, iron, sulfur, and other nutrients. These drastic changes in key …

Streptomycetes sense and respond to the stress of phosphate starvation via the two-
component PhoR–PhoP signal transduction system. To identify the in vivo targets of PhoP …

Phosphate limitation is important for production of antibiotics and other secondary
metabolites in Streptomyces. Phosphate control is mediated by the two-component system …

Bacterial pathogens, including those of humans, animals, and plants, encounter phosphate
(Pi)-limiting or Pi-rich environments in the host, depending on the site of infection. The …

A sigma (σ) factor is a constituent of bacterial RNA polymerase that guides the holoenzyme
to promoter sequences and initiates transcription. In addition to a primary housekeeping σ …

CRISPR–Cas activator (CRISPRa) systems that selectively turn on transcription of a target
gene are a potentially transformative technology for programming cellular function. While in …