Iron is an essential element for numerous fundamental biologic processes, but excess iron is
toxic. Abnormalities in systemic iron balance are common in patients with chronic kidney …

Previously undiagnosed anaemia is common in elective orthopaedic surgical patients and is
associated with increased likelihood of blood transfusion and increased perioperative …

Background Anemia is associated with an increased risk of cardiovascular and renal events
among patients with type 2 diabetes and chronic kidney disease. Although darbepoetin alfa …

Human erythropoietin (Epo) is a 30.4 kDa glycoprotein hormone composed of a single 165
amino acid residues chain to which four glycans are attached. The kidneys are the primary …

The increasing prevalence of older-age people in our society represents the culmination of
centuries of medical, scientific, and social endeavors. At least in Western society, now …

Background: Previous meta-analyses suggest that treatment with erythropoiesis-stimulating
agents (ESAs) in chronic kidney disease (CKD) increases the risk for death. Additional …

The use of alternatives to allogeneic blood continues to rest on the principles that blood
transfusions have inherent risks, associated costs, and affect the blood inventory available …

Background Anaemia associated with cancer and cancer therapy is an important clinical
factor in the treatment of malignant diseases. Therapeutic alternatives are recombinant …

Transplantation-associated thrombotic microangiopathy (TA-TMA) is a challenging
diagnosis after hematopoietic stem cell transplantation. Although endothelial injury …

Anemia is prevalent in 30% to 90% of patients with cancer. Anemia can be corrected
through either treating the underlying cause or providing supportive care through transfusion …