Inflammation in intervertebral disc degeneration and regeneration

M Molinos, CR Almeida, J Caldeira… - Journal of the …, 2015 - royalsocietypublishing.org
Intervertebral disc (IVD) degeneration is one of the major causes of low back pain, a
problem with a heavy economic burden, which has been increasing in prevalence as …

Stem cell therapy for intervertebral disc regeneration: obstacles and solutions

D Sakai, GBJ Andersson - Nature Reviews Rheumatology, 2015 - nature.com
Intervertebral disc (IVD) degeneration is frequently associated with low back and neck pain,
which accounts for disability worldwide. Despite the known outcomes of the IVD …

Stem cell‐recruiting injectable microgels for repairing osteoarthritis

Y Lei, Y Wang, J Shen, Z Cai, Y Zeng… - Advanced Functional …, 2021 - Wiley Online Library
The differentiation potentials and viability of stem cells are often impaired during cell
isolation and delivery. Inspired by the phenomenon where islands can recruit seabirds for …

An overview of injectable polymeric hydrogels for tissue engineering

A Sivashanmugam, RA Kumar, MV Priya… - European Polymer …, 2015 - Elsevier
The desire and need to minimize traditional open surgeries is gearing up as it could reduce
the healthcare expenses and improve the recovery time for the patients. Minimal invasive …

Advancing the cellular and molecular therapy for intervertebral disc disease

D Sakai, S Grad - Advanced drug delivery reviews, 2015 - Elsevier
The healthy intervertebral disc (IVD) fulfils the essential function of load absorption, while
maintaining multi-axial flexibility of the spine. The interrelated tissues of the IVD, the annulus …

Extracellular vesicles as an emerging treatment option for intervertebral disc degeneration: therapeutic potential, translational pathways, and regulatory considerations

TJ DiStefano, K Vaso, G Danias… - Advanced …, 2022 - Wiley Online Library
Emergent approaches in regenerative medicine look toward the use of extracellular vesicles
(EVs) as a next‐generation treatment strategy for intervertebral disc (IVD) degeneration …

Intervertebral disc regeneration: from cell therapy to the development of novel bioinspired endogenous repair strategies

J Clouet, M Fusellier, A Camus, C Le Visage… - Advanced Drug Delivery …, 2019 - Elsevier
Low back pain (LBP), frequently associated with intervertebral disc (IVD) degeneration, is a
major public health concern. LBP is currently managed by pharmacological treatments and …

Immuno-modulatory effects of intervertebral disc cells

P Bermudez-Lekerika, KB Crump… - Frontiers in cell and …, 2022 - frontiersin.org
Low back pain is a highly prevalent, chronic, and costly medical condition predominantly
triggered by intervertebral disc degeneration (IDD). IDD is often caused by structural and …

[HTML][HTML] Mechanisms of endogenous repair failure during intervertebral disc degeneration

K Ma, S Chen, Z Li, X Deng, D Huang, L Xiong… - Osteoarthritis and …, 2019 - Elsevier
Intervertebral disc (IVD) degeneration is frequently associated with Low back pain (LBP),
which can severely reduce the quality of human life and cause enormous economic loss …

Inflammatory mediators and signalling pathways controlling intervertebral disc degeneration

SE Navone, G Marfia, A Giannoni, M Beretta… - Histology and …, 2017 - air.unimi.it
Intervertebral disc (IVD) degeneration (IDD) is one of the major causes of back pain, a
condition that represents a serious socio-economic burden. Deeper knowledge of the …