Drug combination therapy increases successful drug repositioning
Highlights•Publications for drug repositioning have drastically increased in past five
years.•Different types of drug repositioning and available resources have been …
years.•Different types of drug repositioning and available resources have been …
PfCRT and its role in antimalarial drug resistance
Plasmodium falciparum resistance to chloroquine, the former gold standard antimalarial
drug, is mediated primarily by mutant forms of the chloroquine resistance transporter …
drug, is mediated primarily by mutant forms of the chloroquine resistance transporter …
Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing
Malaria elimination strategies require surveillance of the parasite population for genetic
changes that demand a public health response, such as new forms of drug resistance,. Here …
changes that demand a public health response, such as new forms of drug resistance,. Here …
Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics
Chemogenetic characterization through in vitro evolution combined with whole-genome
analysis can identify antimalarial drug targets and drug-resistance genes. We performed a …
analysis can identify antimalarial drug targets and drug-resistance genes. We performed a …
The Activities of Current Antimalarial Drugs on the Life Cycle Stages of Plasmodium: A Comparative Study with Human and Rodent Parasites
M Delves, D Plouffe, C Scheurer, S Meister… - PLoS …, 2012 - journals.plos.org
Background Malaria remains a disease of devastating global impact, killing more than
800,000 people every year—the vast majority being children under the age of 5. While …
800,000 people every year—the vast majority being children under the age of 5. While …
Plasmodium Genomics and Genetics: New Insights into Malaria Pathogenesis, Drug Resistance, Epidemiology, and Evolution
Protozoan Plasmodium parasites are the causative agents of malaria, a deadly disease that
continues to afflict hundreds of millions of people every year. Infections with malaria …
continues to afflict hundreds of millions of people every year. Infections with malaria …
Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
We describe an analysis of genome variation in 825 P. falciparum samples from Asia and
Africa that identifies an unusual pattern of parasite population structure at the epicenter of …
Africa that identifies an unusual pattern of parasite population structure at the epicenter of …
Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia
S Takala-Harrison, TG Clark… - Proceedings of the …, 2013 - National Acad Sciences
The recent emergence of artemisinin-resistant Plasmodium falciparum malaria in western
Cambodia could threaten prospects for malaria elimination. Identification of the genetic …
Cambodia could threaten prospects for malaria elimination. Identification of the genetic …
Antimalarial drug resistance and implications for the WHO global technical strategy
Abstract Purpose of Review Five years have passed since the World Health Organization
released its Global Technical Strategy for Malaria (GTS). In that time, progress against …
released its Global Technical Strategy for Malaria (GTS). In that time, progress against …
Transcriptional variation in the malaria parasite Plasmodium falciparum
N Rovira-Graells, AP Gupta, E Planet… - Genome …, 2012 - genome.cshlp.org
Malaria genetic variation has been extensively characterized, but the level of epigenetic
plasticity remains largely unexplored. Here we provide a comprehensive characterization of …
plasticity remains largely unexplored. Here we provide a comprehensive characterization of …