The use of privileged structures in drug discovery has proven to be an effective strategy,
allowing the generation of innovative hits/leads and successful optimization processes …

Coumarin heterocyclic derivatives: chemical synthesis and biological activity - Natural Product
Reports (RSC Publishing) DOI:10.1039/C4NP00162A Royal Society of Chemistry View PDF …

The review is focused on recent developments of chemistry of synthetic analogs of natural
compounds, isoflavone and homoisoflavone. The possible synthetic strategies to access …

Bis‐heterocycles (BHCs) are hybrid molecules comprising two linked, bound, spacer, or
fused heterocyclic skeletons. In recent years, these compounds have attracted increased …

Parasitic diseases have serious health, social, and economic impacts, especially in the
tropical regions of the world. Diseases caused by protozoan parasites are responsible for …

Trichomonas vaginalis is a flagellate protozoan that causes trichomonosis, a sexually
transmitted disease of worldwide importance. However, the infection has long received …

The Escherichia coli neutral M1-aminopeptidase (ePepN) is a novel target identified for the
development of antimicrobials. Here we describe a solid-phase multicomponent approach …

A new, efficient, green, endogenous water-triggered, solvent-and catalyst-free ultrasound-
assisted one-pot Groebke–Blackburn–Bienaymé reaction/SNAr/ring-chain azido …

Endogenous water-triggered and ultrasound accelerated synthesis of 1,5-disubstituted tetrazoles
via a solvent and catalyst-free Ugi-azide reaction - Green Chemistry (RSC Publishing) …

A series of 18 3-tetrazolyl-tetrazolo [1, 5-a] quinolines were synthesized in 21–90% yields
via a novel one-pot Ugi-azide/SNAr/ring–chain azido-tautomerization process. We report …