[HTML][HTML] Mechanistic flexibility of the retrosplenial cortex enables its contribution to spatial cognition

M Stacho, D Manahan-Vaughan - Trends in neurosciences, 2022 - cell.com
The retrosplenial cortex (RC) is a brain structure crucial for spatial navigation and memory. It
contains neurons such as head direction cells, border cells, as well as other cells supporting …

Computational cross‐species views of the hippocampal formation

SL Zhu, KJ Lakshminarasimhan, DE Angelaki - Hippocampus, 2023 - Wiley Online Library
The discovery of place cells and head direction cells in the hippocampal formation of freely
foraging rodents has led to an emphasis of its role in encoding allocentric spatial …

The entorhinal cognitive map is attracted to goals

CN Boccara, M Nardin, F Stella, J O'Neill, J Csicsvari - Science, 2019 - science.org
Grid cells with their rigid hexagonal firing fields are thought to provide an invariant metric to
the hippocampal cognitive map, yet environmental geometrical features have recently been …

[HTML][HTML] Shared and specialized coding across posterior cortical areas for dynamic navigation decisions

SY Tseng, SN Chettih, C Arlt, R Barroso-Luque… - Neuron, 2022 - cell.com
Animals adaptively integrate sensation, planning, and action to navigate toward goal
locations in ever-changing environments, but the functional organization of cortex …

Dissociation between postrhinal cortex and downstream parahippocampal regions in the representation of egocentric boundaries

X Gofman, G Tocker, S Weiss, CN Boccara, L Lu… - Current Biology, 2019 - cell.com
Navigation requires the integration of many sensory inputs to form a multi-modal cognitive
map of the environment, which is believed to be implemented in the hippocampal region by …

Thalamus and claustrum control parallel layer 1 circuits in retrosplenial cortex

EKW Brennan, I Jedrasiak-Cape, S Kailasa, SP Rice… - Elife, 2021 - elifesciences.org
The granular retrosplenial cortex (RSG) is critical for both spatial and non-spatial behaviors,
but the underlying neural codes remain poorly understood. Here, we use optogenetic circuit …

Progressive impairment of directional and spatially precise trajectories by TgF344-Alzheimer's disease rats in the Morris Water Task

LE Berkowitz, RE Harvey, E Drake, SM Thompson… - Scientific reports, 2018 - nature.com
Spatial navigation is impaired in early stages of Alzheimer's disease, and may be a defining
behavioral marker of preclinical AD. A new rat model (TgF344-AD) of AD overcomes many …

Running speed and REM sleep control two distinct modes of rapid interhemispheric communication

M Ghosh, FC Yang, SP Rice, V Hetrick, AL Gonzalez… - Cell reports, 2022 - cell.com
Rhythmic gamma-band communication within and across cortical hemispheres is critical for
optimal perception, navigation, and memory. Here, using multisite recordings in both rats …

A thalamic reticular circuit for head direction cell tuning and spatial navigation

G Vantomme, Z Rovó, R Cardis, E Béard, G Katsioudi… - Cell reports, 2020 - cell.com
As we navigate in space, external landmarks and internal information guide our movement.
Circuit and synaptic mechanisms that integrate these cues with head-direction (HD) signals …

Distribution and overlap of entorhinal, premotor, and amygdalar connections in the monkey anterior cingulate cortex

SM Calderazzo, SE Busch, TL Moore… - Journal of …, 2021 - Wiley Online Library
The anterior cingulate cortex (ACC) is important for decision‐making as it integrates motor
plans with affective and contextual limbic information. Disruptions in these networks have …