This review examines recent advances in the study of the behavioral responses to deficits of
body water and body sodium that in humans are accompanied by the sensations of thirst …

The brain's three sensory circumventricular organs, the subfornical organ, organum
vasculosum of the lamina terminalis and the area postrema lack a blood brain barrier and …

Renin was first isolated in the kidney by Tigerstedt and Bergman over 100 years ago. Almost
50 additional years were necessary to isolate the renin substrate angiotensinogen and to …

We examined angiotensinogen gene expression in rat kidney by in situ hybridization
histochemistry. Using a rat cRNA probe to angiotensinogen, we demonstrated …

Angiotensin II receptor antagonist ameliorates renal tubulointerstitial fibrosis caused by
unilateral ureteral obstruction. Unilateral ureteral obstruction (UUO) results in …

The renin–angiotensin system (RAS) is widely recognized as one of the most important
vasoactive hormonal systems in the physiological regulation of blood pressure and the …

To maintain homeostasis autonomic control centers in the hypothalamus and medulla must
respond appropriately to both external and internal stimuli. Although protected behind the …

Vasopeptidase inhibition attenuates the progression of renal injury in subtotal
nephrectomized rats. Background Vasopeptidase inhibitors are a new class of …

Aminopeptidase A (EC 3.4. 11.7, APA) is a homodimeric membrane-bound glycoprotein that
contains the consensus sequence HEXXH (385-389) found in zinc metallopeptidases such …

This study aimed to elucidate whether angiotensin (Ang) II generated de novo at the infarct
site regulates the redox state of inflammatory cells participating in cardiac repair. On days 3 …