The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …

Intracellular delivery of advanced therapeutics, including biologicals and supramolecular
agents, is complex because of the natural biological barriers that have evolved to protect the …

Extracellular matrix (ECM) maintains the structural integrity of tissues and regulates cell and
tissue functions. ECM is comprised of fibrillar proteins, proteoglycans (PGs) …

Hyaluronan (HA) is a linear glycosaminoglycan (GAG) of extracellular matrix (ECM)
synthesized by three hyaluronan synthases (HASes) at the plasma membrane using uridine …

Pancreatic β cell function is compromised in diabetes and is typically assessed by
measuring insulin secretion during glucose stimulation. Traditionally, measurement of …

The extracellular matrix (ECM) provides structural support and imparts a wide variety of
environmental cues to cells. In the past decade, a growing body of work revealed that the …

The biophysical and biomechanical properties of the extracellular matrix (ECM) are crucial
in the processes of cell differentiation and proliferation. However, it is unclear to what extent …

The microvasculature in the pancreatic islet is highly specialized for glucose sensing and
insulin secretion. Although pancreatic islet transplantation is a potentially life-changing …

Atomic force microscopy (AFM) has found a wide range of bio-applications in the past few
decades due to its ability to measure biological samples in natural environments at a high …

The tissue microenvironment contributes to local immunity and to the pathogenesis of
autoimmune diseases-a diverse set of conditions characterized by sterile inflammation …