Knowledge on the mechanisms of acid and base secretion in airways has progressed
recently. The aim of this review is to summarize the known mechanisms of airway surface …

Cystic fibrosis (CF) is a autosomal recessive, multisystemic disease caused by different
mutations in the CFTR gene encoding CF transmembrane conductance regulator. Although …

In vitro cultures of primary human airway epithelial cells (hAECs) grown at air–liquid
interface have become a valuable tool to study airway biology under normal and pathologic …

Cystic fibrosis (CF) human and mouse macrophages are defective in their ability to clear
bacteria such as Burkholderia cenocepacia. The autophagy process in CF (F508del) …

Background In cystic fibrosis (CF), loss of CF transmembrane conductance regulator (CFTR)-
dependent bicarbonate secretion precipitates the accumulation of viscous mucus in the …

For many decades, our understanding of G protein-coupled receptor (GPCR) activity and
cyclic AMP (cAMP) signaling was limited exclusively to the plasma membrane. However, a …

Cystic fibrosis (CF) is a genetic disease caused by mutations in the cystic fibrosis
transmembrane conductance regulator (CFTR) protein, a plasma membrane protein …

The development of preclinical in vitro models has provided significant progress to the
studies of cystic fibrosis (CF), a frequently fatal monogenic disease caused by mutations in …

CFTR, the cystic fibrosis (CF) gene-encoded epithelial anion channel, has a prominent role
in driving chloride, bicarbonate and fluid secretion in the ductal cells of the exocrine …

Simple Summary Cystic fibrosis (CF) is a multi-organ disease that affects the epithelia and
exocrine glands, particularly the lungs, but also the pancreas, liver, kidneys, and intestines …