Meningococcus, an obligate human bacterial pathogen, remains a worldwide and
devastating cause of epidemic meningitis and sepsis. However, advances have been made …

The complement system comprises several fluid-phase and membrane-associated proteins.
Under physiological conditions, activation of the fluid-phase components of complement is …

The complement system consists of both plasma and membrane proteins. The former
influence the inflammatory response, immune modulation, and host defense. The latter are …

Publisher Summary This chapter summarizes the recent knowledge on the production of
cytokines by neutrophils in vitro and in vivo—particularly molecular regulation and other …

The only natural reservoir of Neisseria meningitidis is the human nasopharyngeal mucosa.
Depending on age, climate, country, socioeconomic status, and other factors, approximately …

Sepsis is a major clinical problem for which therapeutic interventions have been largely
unsuccessful, in spite of promising strategies that were successful in animals, especially …

• Introduction• Methods to study and modify the alternative pathway‐Inhibition by
monoclonal antibodies‐Knockout models• Influence of AP amplification on the effect of …

Despite considerable advances in the understanding of the pathogenesis of meningococcal
disease, this infection remains a major cause of morbidity and mortality globally. The role of …

Lipooligosaccharides (LOSs) are the major glycolipids expressed on mucosal Gram-
negative bacteria, including members of the genera Neisseria, Haemophilus, Bordetella …

Bacterial meningitis remains a disease with associated unacceptable morbidity and mortality
rates despite the availability of effective bactericidal antimicrobial therapy. Through the use …