When Folkman first suggested a theory about the association between angiogenesis and
tumor growth in 1971, the hypothesis of targeting angiogenesis to treat cancer was formed …

Basement membranes are widely distributed extracellular matrices that coat the basal
aspect of epithelial and endothelial cells and surround muscle, fat, and Schwann cells …

Lung epithelial cells have emerged as a frequent target of injury, a driver of normal repair,
and a key element in the pathobiology of fibrotic lung diseases. An important aspect of …

The collagen family of extracellular matrix proteins has played a fundamental role in the
evolution of multicellular animals. At the present, 28 triple helical proteins have been named …

Biochemistry of Collagens, Laminins, and Elastin: Structure, Function and Biomarkers, Third
Edition provides current data on key structural proteins (collagens, laminins, and elastin) …

Pulmonary fibrosis, in particular idiopathic pulmonary fibrosis (IPF), results from aberrant
wound healing and scarification. One population of fibroblasts involved in the fibrotic …

Angiogenesis, the formation of new blood vessels from preexisting vasculature, contributes
to the pathogenesis of many disorders, including ischemic diseases and cancer. Integrins …

The remodeling of the extracellular matrix (ECM) by several protease families releases a
number of bioactive fragments, which regulate numerous biological processes such as …

Integrins are transmembrane heteromeric receptors that mediate interactions between cells
and extracellular matrix (ECM). β1, the most abundantly expressed integrin subunit, binds at …

Integrins are heterodimeric cell surface receptors composed of α and β subunits that control
adhesion, proliferation and gene expression. The integrin heterodimer binding to ligand …