Importance of the field: Antipsychotic drug is the mainstay of treatment for schizophrenia,
and there are large inter-individual differences in clinical response and side effects …

Olanzapine, aripiprazole and risperidone are atypical antipsychotics or neuroleptics widely
used for schizophrenia treatment. They induce various adverse drug reactions depending …

Objective: Pharmacogenomic studies of antipsychotics have typically examined effects of
individual polymorphisms. By contrast, polygenic risk scores (PRSs) derived from genome …

Objective: During the past decades, increasing efforts have been invested in studies to
unravel the influence of genetic factors on antipsychotic (AP) dosage, treatment response …

Aripiprazole was the first antipsychotic developed to possess agonist properties at
dopamine D2 autoreceptors, a groundbreaking strategy that presented a new vista for …

Adverse events, response failures and medication non-compliance are common in patients
receiving medications for the treatment of mental illnesses. A systematic literature review …

Second-generation antipsychotics are widely used for the treatment of schizophrenia.
Aripiprazole (ARI) is classified as a third-generation antipsychotic drug with a high affinity for …

Oral aripiprazole (Abilify®) is an atypical antipsychotic agent that is approved worldwide for
use in adult patients with schizophrenia. It is a quinolinone derivative that has a unique …

Dopamine D2 and serotonin 5-HT2A receptors contribute to modulate prefrontal cortical
physiology and response to treatment with antipsychotics in schizophrenia. Similarly …

Abstract The serotonin 2A receptor (5‐HT2AR) is implicated in the pathophysiology and
treatment of various psychiatric disorders.[18F] altanserin and [11C] Cimbi‐36 positron …