Cytolethal distending toxin (CDT) is a heterotrimeric AB-type genotoxin produced by several
clinically important Gram-negative mucocutaneous bacterial pathogens. Irrespective of the …

Disruption of the mechanisms that regulate cell-cycle checkpoints, DNA repair, and
apoptosis results in genomic instability and the development of cancer in multicellular …

UV-induced DNA damage stalls DNA replication forks and activates the intra-S checkpoint to
inhibit replicon initiation. In response to stalled replication forks, ATR phosphorylates and …

Eukaryotic cells respond to DNA damage within the S phase by activating an intra-S
checkpoint: a response that includes reducing the rate of DNA synthesis. In yeast cells this …

We have investigated mechanisms that recruit the translesion synthesis (TLS) DNA
polymerase Polκ to stalled replication forks. The DNA polymerase processivity factor PCNA …

Previously we identified an intra-S-phase cell cycle checkpoint elicited by the DNA-
damaging carcinogen benzo [a] pyrene-dihydrodiol epoxide (BPDE). Here we have …

DNA damage induced by the carcinogen benzo [a] pyrene dihydrodiol epoxide (BPDE)
induces a Chk1-dependent S-phase checkpoint. Here, we have investigated the molecular …

The cellular response to DNA damage is composed of cell cycle checkpoint and DNA repair
mechanisms that serve to ensure proper replication of the genome prior to cell division. The …

Caffeoylquinic acid (CQA) is a natural polyphenol with evidence of antioxidant and
neuroprotective effects and prevention of deficits in spatial learning and memory. We studied …

Heterozygous mutations in the tumor suppressor BRCA2 confer a high risk of breast and
other cancers in humans. BRCA2 maintains genome stability in part through the regulation …