Background Infective Endocarditis (IE) and Sepsis are two closely related infectious
diseases, yet their shared pathogenic mechanisms at the transcriptional level remain …

Background The genetics of male fertility is complex and not fully understood. Male
subfertility can adversely affect the economics of livestock production. For example …

Introduction It is important to control both inflammation and immunosuppression after severe
insults, such as sepsis, trauma, and surgery. Endotoxin tolerance is one of the …

Interleukin-1 receptor-associated kinase 3 (IRAK3) modulates the magnitude of cellular
responses to ligands perceived by interleukin-1 receptors (IL-1Rs) and Toll-like receptors …

Bacterial sepsis characterised by an immunosuppressive and cytokine storm state is a
challenge to treat clinically. While conventional antibiotics have been associated with …

Adenosine monophosphate-activated protein kinase (AMPK) is involved in suppression of
the development of endotoxin tolerance, which is a driver of the immunosuppression …

The mortality caused by tuberculosis (TB) infections is a global concern, and there is a need
to improve understanding of the disease. Current in vitro infection models to study the …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the current
pandemic coronavirus disease 2019 (COVID-19). Dysregulated and excessive production of …

The anti-inflammatory interleukin-1 receptor associated kinase-M (IRAK-M) is a negative
regulator of MyD88/IRAK-4/IRAK-1 signaling. However, IRAK-M has also been reported to …

Microbial resistance to antibiotics poses a tremendous challenge. Bacteriophages may
provide a useful alternative or adjunct to traditional antibiotics. To be used in therapy …