Abnormal choline metabolism continues to be identified in multiple cancers. Molecular
causes of abnormal choline metabolism are changes in choline kinase-α, ethanolamine …

It is well established that lipid metabolism is drastically altered during tumor development
and response to therapy. Choline kinase alpha (ChoKα) is a key mediator of these changes …

Protein O-glycosylation is controlled by polypeptide GalNAc-transferases (GalNAc-Ts) that
uniquely feature both a catalytic and lectin domain. The underlying molecular basis of how …

Endometrial cancer (EC) is a common malignant tumor that is closely associated with
metabolic disorders such as diabetes and obesity. Advanced glycation end products (AGEs) …

A plethora of technological applications justify why titanium dioxide is probably the most
studied oxide, and an optimal exploitation of its properties quite frequently requires a …

Upregulated choline metabolism, characterized by an increase in phosphocholine (PCho),
is a hallmark of oncogenesis and tumor progression. Choline kinase (ChoK), the enzyme …

Choline kinase α (ChoKα) is an enzyme involved in the synthesis of phospholipids and
thereby plays key roles in regulation of cell proliferation, oncogenic transformation, and …

Since the identification of human choline kinase as a protein target against cancer
progression, many compounds have been designed to inhibit its function and reduce the …

A novel family of compounds derivative of 1, 1′-(((ethane-1, 2-diylbis (oxy)) bis (4, 1-
phenylene)) bis (methylene))-bispyridinium or–bisquinolinium bromide (10a-l) containing a …

Simple Summary We found that low expression of ATP8B1 was associated with poor
prognosis, and involved in the dysregulation of glutathione (GSH) synthesis and choline …