Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …

Obesity has become a global epidemic that has a negative impact on population health and
the economy of nations. Genetic predispositions have been demonstrated to have a …

Diabetes is a leading cause of morbidity and mortality worldwide, and predicted to affect
over 500 million people by 2030. However, this growing burden of disease has not been met …

Nutritional factors play a life-long role in human health. Indeed, there is growing evidence
that one of the mechanisms by which nutrients and bioactive compounds affect metabolic …

HDACs (histone deacetylases) are a group of enzymes that deacetylate histones as well as
non-histone proteins. They are known as modulators of gene transcription and are …

One of the major disappointments in human autoimmunity has been the relative failure on
genome-wide association studies to provide “smoking genetic guns” that would explain the …

Immune-mediated diseases are clinically heterogeneous but they share genetic and
pathogenic mechanisms. These diseases may develop from the interplay of genetic factors …

Abstract Type 1 diabetes (T1D) also known as juvenile diabetes is a chronic autoimmune
disorder that precipitates in genetically susceptible individuals by environmental factors …

The progression of cancer is a result of not only the growth of the malignant cells but also the
behavior of other components of the tumor microenvironment (TME). Tumor-associated …

The prevalence of type 2 diabetes (T2D) is rapidly increasing worldwide. Obesity, physical
inactivity and ageing increase the risk of T2D. Epigenetic modifications can change due to …