Mitochondria, ubiquitous double-membrane-bound organelles, regulate energy production,
support cellular activities, harbor metabolic pathways, and, paradoxically, mediate cell fate …

Previous studies have shown that mitochondria play core roles in not only cancer stem cell
(CSC) metabolism but also the regulation of CSC stemness maintenance and differentiation …

Cancer-associated fibroblasts (CAFs) are the most abundant stromal components in the
tumor microenvironment (TME) and closely involved in tumor progression. However, the …

Phosphatases and kinases maintain an equilibrium of dephosphorylated and
phosphorylated proteins, respectively, that are required for critical cellular functions …

Background Drug resistance limits the treatment effect of cisplatin-based chemotherapy in
head and neck squamous cell carcinoma (HNSCC), and the underlying mechanism is not …

Oxaliplatin is the main chemotherapy drug for gastric cancer (GC), but quite a few patients
are resistant to oxaliplatin, which contributes to the poor prognosis of GC patients. There is …

Abstract Tumor protein 53 (TP53) mutation in bladder carcinoma (BC), upregulates the
transcription of carbamoyl phosphate synthetase 1 (CPS1), to reduce intracellular ammonia …

Marine seaweeds are predominant for nutraceuticals and have been food source since
ancient times and are currently being used in Chinese medicines and Japanese traditional …

Background Chemoresistance is a main obstacle in gastric cancer (GC) treatment, but its
molecular mechanism still needs to be elucidated. Here, we aim to reveal the underlying …

Background Fibrosis is a tissue damage repair response caused by multiple pathogenic
factors which could occur in almost every apparatus and leading to the tissue structure …