In contrast to nitric oxide, which has well established and important roles in the regulation of
blood flow and thrombosis, neurotransmission, the normal functioning of the genitourinary …

ContextThe efficient sequestration of hemoglobin by the red blood cell membrane and the
presence of multiple hemoglobin clearance mechanisms suggest a critical need to prevent …

Although the deleterious vasoconstrictive effects of cell-free, hemoglobin-based blood
substitutes have been appreciated, the systemic effects of chronic hemolysis on nitric oxide …

Endothelial nitric oxide (nitrogen monoxide) is synthesized at the intravascular/extravascular
interface. We previously have reported the intravascular half-life of NO, as a result of …

After several decades of intensive efforts, safe injectable preparations capable of effectively
delivering O2 to tissues and removing CO2, ie, so-called blood substitutes, appear to be …

The synthesis of nitric oxide (NO) in the circulation has been attributed exclusively to the
vascular endothelium. Red blood cells (RBCs) have been demonstrated to carry a …

The plasma level of NOx, ie, the sum of NO2− and NO3−, is frequently used to assess NO
bioavailability in vivo. However, little is known about the kinetics of NO conversion to these …

Erythrocytes regulate vascular function through the modulation of oxygen delivery and the
scavenging and generation of nitric oxide (NO). First, hemoglobin inside the red blood cell …

Nitric oxide (NO•; nitrogen monoxide) is known to be a critical regulator of cell and tissue
function through mechanisms that utilize its unique physicochemical properties as a small …

Hemoglobin has functions besides carrying oxygen to the tissues, and regulates vascular
tone and inflammation via a redox couple with methemoglobin. Hemoglobin has iron in the …