Human immune diversity: from evolution to modernity

A Liston, S Humblet-Baron, D Duffy, A Goris - Nature immunology, 2021 - nature.com
The extreme diversity of the human immune system, forged and maintained throughout
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …

Clonal haematopoiesis and dysregulation of the immune system

R Belizaire, WJ Wong, ML Robinette… - Nature Reviews …, 2023 - nature.com
Age-related diseases are frequently linked to pathological immune dysfunction, including
excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human …

Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis

AJ Kwok, A Allcock, RC Ferreira, E Cano-Gamez… - Nature …, 2023 - nature.com
Sepsis arises from diverse and incompletely understood dysregulated host response
processes following infection that leads to life-threatening organ dysfunction. Here we …

Common and rare variant associations with clonal haematopoiesis phenotypes

MD Kessler, A Damask, S O'Keeffe, N Banerjee, D Li… - Nature, 2022 - nature.com
Clonal haematopoiesis involves the expansion of certain blood cell lineages and has been
associated with ageing and adverse health outcomes,,,–. Here we use exome sequence …

[HTML][HTML] Clonal dynamics of haematopoiesis across the human lifespan

E Mitchell, M Spencer Chapman, N Williams… - Nature, 2022 - nature.com
Age-related change in human haematopoiesis causes reduced regenerative capacity,
cytopenias, immune dysfunction and increased risk of blood cancer,–, but the reason for …

Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis

SP Kar, PM Quiros, M Gu, T Jiang, J Mitchell… - Nature Genetics, 2022 - nature.com
Clonal hematopoiesis (CH), the clonal expansion of a blood stem cell and its progeny driven
by somatic driver mutations, affects over a third of people, yet remains poorly understood …

Distinction of lymphoid and myeloid clonal hematopoiesis

A Niroula, A Sekar, MA Murakami, M Trinder… - Nature medicine, 2021 - nature.com
Clonal hematopoiesis (CH) results from somatic genomic alterations that drive clonal
expansion of blood cells. Somatic gene mutations associated with hematologic …

Genetics and epidemiology of mutational barcode-defined clonal hematopoiesis

SN Stacey, F Zink, GH Halldorsson, L Stefansdottir… - Nature Genetics, 2023 - nature.com
Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is
derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of …

Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A Mendelian randomisation study

FW Hamilton, M Thomas, D Arnold, T Palmer… - PLoS …, 2023 - journals.plos.org
Background Sepsis is characterised by dysregulated, life-threatening immune responses,
which are thought to be driven by cytokines such as interleukin 6 (IL-6). Genetic variants in …

Clonal hematopoiesis of indeterminate potential (CHIP): Linking somatic mutations, hematopoiesis, chronic inflammation and cardiovascular disease

CS Marnell, A Bick, P Natarajan - Journal of molecular and cellular …, 2021 - Elsevier
Clonal hematopoiesis of indeterminate potential (CHIP) is the presence of a clonally
expanded hematopoietic stem cell caused by a leukemogenic mutation in individuals …