Glycosylation is the most abundant and complex protein modification, and can have a
profound structural and functional effect on the conjugate. The oligosaccharide fraction is …

Impaired cellular homeostasis of metals, particularly of Cu, Fe and Mn may trigger
neurodegeneration through various mechanisms, notably induction of oxidative stress …

The aim of this study was to assess the impact of diet and active substances in beetroot juice
on the parameters of oxidative stress, inflammation, and muscle damage as well as on the …

The fraction of copper not bound to ceruloplasmin seems altered in Alzheimer's disease
(AD). We have addressed this notion evaluating all the studies carried out from 1996 until …

Labile copper (II) ions (Cu2+) in serum are considered to be readily available for cellular
uptake and to constitute the biologically active Cu2+ species in the blood. It might also be …

Wilson disease (WD) is an autosomal recessive inherited disorder of copper metabolism.
Failure to diagnose WD can be dramatic leading to irreversible damages. The molecular …

Direct, site-specific methods of protein functionalization are highly desirable for
biotechnology. However, such methods are challenging due to the difficulty of chemically …

Wilson's disease is an autosomal recessive disorder of copper metabolism. The culprit gene
is ATP7B. The worldwide prevalence is about 1 in 30,000, which may vary by population …

Exchangeable copper (CuEXC), mainly comprised copper (Cu) bound to albumin, has been
proposed as a specific marker of Cu overload in Wilson's disease (WD). To the author's …

Element analysis in clinical or biological samples is important due to the essential role in
clinical diagnostics, drug development, and drug-effect monitoring. Particularly, the specific …