Recent advances in sequencing techniques that measure nascent transcripts and that
reveal the positioning of RNA polymerase II (Pol II) have shown that the pausing of Pol II in …

Maturation of mRNA precursors often occurs simultaneously with their synthesis by RNA
polymerase II (Pol II). The co-transcriptional nature of mRNA processing has permitted the …

Production of mRNA depends critically on the rate of RNA polymerase II (Pol II) elongation.
To dissect Pol II dynamics in mouse ES cells, we inhibited Pol II transcription at either …

Gene expression is controlled in a dynamic and regulated manner to allow for the consistent
and steady expression of some proteins as well as the rapidly changing production of other …

The human transcriptome comprises> 80000 protein-coding transcripts and the estimated
number of proteins synthesized from these transcripts is in the range of 250000 to 1 million …

Transcription termination occurs when the polymerase is released after a transcription event,
thus delimitating transcription units; however, the functional importance of termination …

We have ablated the cellular RNA degradation machinery in differentiated B cells and
pluripotent embryonic stem cells (ESCs) by conditional mutagenesis of core (Exosc3) and …

The regulation of transcription by RNA polymerase II is closely intertwined with the
regulation of chromatin structure. A host of proteins required for the disassembly …

Accurate DNA replication and DNA repair are crucial for the maintenance of genome
stability, and it is generally accepted that failure of these processes is a major source of DNA …

The torpedo model of transcription termination asserts that the exonuclease Xrn2 attacks the
5′ PO 4-end exposed by nascent RNA cleavage and chases down the RNA polymerase …