There are ample genetic and laboratory studies that suggest the PI3K–Akt pathway is vital to
the growth and survival of cancer cells. Inhibitors targeting this pathway are entering the …

Developmental lung biology is a field that has the potential for significant human impact:
lung disease at the extremes of age continues to cause major morbidity and mortality …

Somatic mutations that activate phosphoinositide 3-kinase (PI3K) have been identified in the
p110-α catalytic subunit (encoded by PIK3CA). They are most frequently observed in two …

To directly test the contribution of Scgb1a1+ Clara cells to postnatal growth, homeostasis,
and repair of lung epithelium, we generated a Scgb1a1-CreER TM" knockin" mouse for …

Abnormally activated RAS proteins are the main oncogenic driver that governs the
functioning of major signaling pathways involved in the initiation and development of human …

Metastatic disease is a primary cause of cancer-related death, and factors governing tumor
cell metastasis have not been fully elucidated. Here, we address this question by using …

Identifying the cells of origin of lung cancer may lead to new therapeutic strategies. Previous
work has focused upon the putative bronchoalveolar stem cell at the bronchioalveolar duct …

Much controversy surrounds the cell-of-origin of mutant K-Ras (K-RasG12D)–induced lung
adenocarcinoma. To shed light on this issue, we have used technology that enables us to …

EXECUTIVE SUMMARY The University of Vermont College of Medicine and the Vermont
Lung Center, with support of the National Heart, Lung, and Blood Institute (NHLBI), the …

Therapies inhibiting receptor tyrosine kinases (RTKs) are effective against some human
cancers when they lead to simultaneous downregulation of PI3K/AKT and MEK/ERK …