Mitochondria are quantifiably the most important sources of superoxide (O2●−) and
hydrogen peroxide (H2O2) in mammalian cells. The overproduction of these molecules has …

Antioxidant supplements are commonly consumed by endurance athletes to minimize
exercise-induced oxidative stress, with the intention of enhancing recovery and improving …

The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and
its dysregulation underlies many chronic diseases. Mitochondria have been implicated as …

Significance: Mitochondrial (mt) reticulum network in the cell possesses amazing
ultramorphology of parallel lamellar cristae, formed by the invaginated inner mitochondrial …

Mitochondria are a main source of cellular energy. Oxidative phosphorylation (OXPHOS) is
the major process of aerobic respiration. Enzyme complexes of the electron transport chain …

Physiologists often assume that mitochondria are the main producers of reactive oxygen
species (ROS) in cells. Consequently, in biomedicine, mitochondria are considered as …

Elevated mitochondrial matrix superoxide and/or hydrogen peroxide concentrations drive a
wide range of physiological responses and pathologies. Concentrations of superoxide and …

The activity of the mitochondrial permeability transition pore, mPTP, a highly regulated multi-
component mega-channel, is enhanced in aging and in aging-driven degenerative …

Some aquaporins (AQPs) can transport H 2 O 2 across membranes, allowing redox signals
to proceed in and between cells. Unlike other peroxiporins, human AQP11 is an …

High-intensity exercise damages mitochondrial DNA (mtDNA) in skeletal muscle. Whether
MitoQ-a redox active mitochondrial targeted quinone-can reduce exercise-induced mtDNA …