Catalysis and Electron Transfer in De Novo Designed Metalloproteins
One of the hallmark advances in our understanding of metalloprotein function is showcased
in our ability to design new, non-native, catalytically active protein scaffolds. This review …
in our ability to design new, non-native, catalytically active protein scaffolds. This review …
Lytic polysaccharide monooxygenases: enzymes for controlled and site-specific Fenton-like chemistry
B Bissaro, VGH Eijsink - Essays in biochemistry, 2023 - portlandpress.com
The discovery of oxidative cleavage of glycosidic bonds by enzymes currently known as lytic
polysaccharide monooxygenases (LPMOs) has profoundly changed our current …
polysaccharide monooxygenases (LPMOs) has profoundly changed our current …
A conserved second sphere residue tunes copper site reactivity in lytic polysaccharide monooxygenases
Lytic polysaccharide monooxygenases (LPMOs) are powerful monocopper enzymes that
can activate strong C–H bonds through a mechanism that remains largely unknown. Herein …
can activate strong C–H bonds through a mechanism that remains largely unknown. Herein …
Fenton-like Chemistry by a Copper(I) Complex and H2O2 Relevant to Enzyme Peroxygenase C–H Hydroxylation
B Kim, MT Brueggemeyer, WJ Transue… - Journal of the …, 2023 - ACS Publications
Lytic polysaccharide monooxygenases have received significant attention as catalytic
convertors of biomass to biofuel. Recent studies suggest that its peroxygenase activity (ie …
convertors of biomass to biofuel. Recent studies suggest that its peroxygenase activity (ie …
The “life-span” of lytic polysaccharide monooxygenases (LPMOs) correlates to the number of turnovers in the reductant peroxidase reaction
Lytic polysaccharide monooxygenases (LPMOs) are monocopper enzymes that degrade the
insoluble crystalline polysaccharides cellulose and chitin. Besides the H 2 O 2 cosubstrate …
insoluble crystalline polysaccharides cellulose and chitin. Besides the H 2 O 2 cosubstrate …
Amyloid fibrils formed by short prion-inspired peptides are metalloenzymes
Enzymes typically fold into defined 3D protein structures exhibiting a high catalytic efficiency
and selectivity. It has been proposed that the earliest enzymes may have arisen from the self …
and selectivity. It has been proposed that the earliest enzymes may have arisen from the self …
Functional and protective hole hopping in metalloenzymes
HB Gray, JR Winkler - Chemical Science, 2021 - pubs.rsc.org
Electrons can tunnel through proteins in microseconds with a modest release of free energy
over distances in the 15 to 20 Å range. To span greater distances, or to move faster, multiple …
over distances in the 15 to 20 Å range. To span greater distances, or to move faster, multiple …
Expanding the catalytic landscape of metalloenzymes with lytic polysaccharide monooxygenases
Lytic polysaccharide monooxygenases (LPMOs) have an essential role in global carbon
cycle, industrial biomass processing and microbial pathogenicity by catalysing the oxidative …
cycle, industrial biomass processing and microbial pathogenicity by catalysing the oxidative …
Deciphering the oxygen activation mechanism at the CuC site of particulate methane monooxygenase
The enzymatic oxidation of methane to methanol was discovered in methanotrophs over 110
years ago. Nevertheless, the mechanism of action of particulate methane monooxygenase …
years ago. Nevertheless, the mechanism of action of particulate methane monooxygenase …
Insights into the H2O2‐driven catalytic mechanism of fungal lytic polysaccharide monooxygenases
Fungal lytic polysaccharide monooxygenases (LPMOs) depolymerise crystalline cellulose
and hemicellulose, supporting the utilisation of lignocellulosic biomass as a feedstock for …
and hemicellulose, supporting the utilisation of lignocellulosic biomass as a feedstock for …