Autophagy is a highly conserved catabolic process induced under various conditions of
cellular stress, which prevents cell damage and promotes survival in the event of energy or …

Targeted protein degradation (TPD) provides unprecedented opportunities for drug
discovery. While the proteolysis-targeting chimera (PROTAC) technology has already …

Aims Cuproptosis is a recently identified form of programmed cell death; however, its role in
hepatocellular carcinoma (HCC) remains unclear. Methods A set of bioinformatic tools was …

Damage-associated molecular pattern molecules (DAMPs) are endogenous danger signals
that alert the innate immune system and shape the inflammation response to cell death …

From yeast to mammals, autophagy is an important mechanism for sustaining cellular
homeostasis through facilitating the degradation and recycling of aged and cytotoxic …

The immunogenicity of cancer cells is an emerging determinant of anti‐cancer
immunotherapy. Beyond developing immunostimulatory regimens like dendritic cell‐based …

Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …

Although it was thought that apoptotic cells, when rapidly phagocytosed, underwent a silent
death that did not trigger an immune response, in recent years a new concept of …

Autophagy is an intracellular bulk degradation system that is highly conserved in
eukaryotes. The discovery of autophagy-related ('ATG') proteins in the 1990s greatly …