Furin catalyses a simple biochemical reaction—the proteolytic maturation of proprotein
substrates in the secretory pathway. But the simplicity of this reaction belies furin's broad and …

Ebolavirus (EBOV) is a highly virulent pathogen capable of causing a severe hemorrhagic
fever with 50–90% lethality. The EBOV glycoprotein (GP) is the only virally expressed …

In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus
and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins …

Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is a rapidly
emerging pathogen with potentially serious consequences for public health. Here we …

Ebola virus exhibits a broad cellular tropism in vitro. In humans and animal models, virus is
found in most tissues and organs during the latter stages of infection. In contrast, a more …

Mammalian cells employ numerous innate cellular mechanisms to inhibit viral replication
and spread. Tetherin, also known as Bst-2 or CD317, is a recently identified, IFN-induced …

Filoviruses, represented by the genera Ebolavirus and Marburgvirus, cause a lethal
hemorrhagic fever in humans and in nonhuman primates. Although filovirus can replicate in …

ABSTRACT Tetherin (CD317/BST-2), an interferon-induced membrane protein, restricts the
release of nascent retroviral particles from infected cell surfaces. While human …

Crimean-Congo hemorrhagic fever (CCHF) is a severe illness with high case fatality that
occurs in Africa, Europe, the Middle East, and Asia. The complete genomes of 13 …

The filoviruses, marburgvirus and ebolavirus, cause epidemics of haemorrhagic fever with
high casefatality rates. The severe illness results from a complex of pathogenetic …