Biofilm lifestyle in recurrent urinary tract infections

ASA Lila, AAH Rajab, MH Abdallah, SMD Rizvi, A Moin… - Life, 2023 - mdpi.com
Urinary tract infections (UTIs) represent one of the most common infections that are
frequently encountered in health care facilities. One of the main mechanisms used by …

[HTML][HTML] What's old is new again: Insights into diabetic foot microbiome

AAH Rajab, WAH Hegazy - World Journal of Diabetes, 2023 - ncbi.nlm.nih.gov
Diabetes is a chronic disease that is considered one of the most stubborn global health
problems that continues to defy the efforts of scientists and physicians. The prevalence of …

Characterization of the anti-biofilm and anti-quorum sensing activities of the β-adrenoreceptor antagonist atenolol against gram-negative bacterial pathogens

S Cavalu, SS Elbaramawi, AG Eissa… - International Journal of …, 2022 - mdpi.com
The development of bacterial resistance to antibiotics is an increasing public health issue
that worsens with the formation of biofilms. Quorum sensing (QS) orchestrates the bacterial …

Drug repositioning: doxazosin attenuates the virulence factors and biofilm formation in Gram-negative bacteria

MA Elfaky, SS Elbaramawi, AG Eissa… - Applied Microbiology …, 2023 - Springer
The resistance development is an increasing global health risk that needs innovative
solutions. Repurposing drugs to serve as anti-virulence agents is suggested as an …

Diminishing the Pathogenesis of the Food-Borne Pathogen Serratia marcescens by Low Doses of Sodium Citrate

MT Khayat, SS Elbaramawi, SI Nazeih, MK Safo… - Biology, 2023 - mdpi.com
Simple Summary Sodium citrate is a safe and frequently used food additive; the objective of
this study is to assess the effectiveness of sodium citrate at low concentrations of 4% or 5 …

Controlling of Bacterial Virulence: Evaluation of Anti-Virulence Activities of Prazosin against Salmonella enterica

MA Elfaky, AK Thabit, K Eljaaly, A Zawawi… - Antibiotics, 2022 - mdpi.com
Salmonella enterica is a Gram-negative orofecal transmitted pathogen that causes a wide
diversity of local and systemic illnesses. Salmonella enterica utilizes several interplayed …

Relocating Glyceryl Trinitrate as an Anti-Virulence Agent against Pseudomonas aeruginosa and Serratia marcescens: Insights from Molecular and In Vivo …

SI Nazeih, MAM Ali, ASA Halim, H Al-Lawati, HA Abbas… - Microorganisms, 2023 - mdpi.com
The problem of antibiotic resistance is a global critical public health concern. In light of the
threat of returning to the pre-antibiotic era, new alternative approaches are required such as …

The anti-virulence activities of the antihypertensive drug propranolol in light of its anti-quorum sensing effects against Pseudomonas aeruginosa and Serratia …

HF Alotaibi, H Alotaibi, KM Darwish, ES Khafagy… - Biomedicines, 2023 - mdpi.com
The development of bacterial resistance is an increasing global concern that requires
discovering new antibacterial agents and strategies. Bacterial quorum sensing (QS) systems …

Hiring of the Anti-Quorum Sensing Activities of Hypoglycemic Agent Linagliptin to Alleviate the Pseudomonas aeruginosa Pathogenesis

MT Khayat, TS Ibrahim, KM Darwish, AN Khayyat… - Microorganisms, 2022 - mdpi.com
Bacteria communicate with each other using quorum sensing (QS) which works in an
inducer/receptor manner. QS plays the main role in orchestrating diverse bacterial virulence …

Synergistic Benefits: Exploring the Anti-Virulence Effects of Metformin/Vildagliptin Antidiabetic Combination against Pseudomonas aeruginosa via Controlling …

MT Khayat, HA Abbas, TS Ibrahim, SS Elbaramawi… - Biomedicines, 2023 - mdpi.com
The repurposing of drugs is one of the most competent strategies for discovering new
antimicrobial agents. Vildagliptin is a dipeptidyl peptidase-4 inhibitor (DPI-4) that is used …