Genomic targets of nuclear estrogen receptors
R O'Lone, MC Frith, EK Karlsson… - Molecular …, 2004 - academic.oup.com
Estrogen influences the physiology of many target tissues in both women and men. The long-
term effects of estrogen are mediated predominantly by nuclear estrogen receptors (ERs) …
term effects of estrogen are mediated predominantly by nuclear estrogen receptors (ERs) …
[HTML][HTML] ATF3, a hub of the cellular adaptive-response network, in the pathogenesis of diseases: is modulation of inflammation a unifying component?
Abstract Activating transcription factor 3 (ATF3) gene encodes a member of the ATF family of
transcription factors and is induced by various stress signals. All members of this family …
transcription factors and is induced by various stress signals. All members of this family …
Molecular signatures underlying neurofibrillary tangle susceptibility in Alzheimer's disease
Tau aggregation in neurofibrillary tangles (NFTs) is closely associated with
neurodegeneration and cognitive decline in Alzheimer's disease (AD). However, the …
neurodegeneration and cognitive decline in Alzheimer's disease (AD). However, the …
[HTML][HTML] Microglial brain region− dependent diversity and selective regional sensitivities to aging
Microglia have critical roles in neural development, homeostasis and neuroinflammation
and are increasingly implicated in age-related neurological dysfunction. Neurodegeneration …
and are increasingly implicated in age-related neurological dysfunction. Neurodegeneration …
[HTML][HTML] iRegulon: from a gene list to a gene regulatory network using large motif and track collections
R Janky, A Verfaillie, H Imrichová… - PLoS computational …, 2014 - journals.plos.org
Identifying master regulators of biological processes and mapping their downstream gene
networks are key challenges in systems biology. We developed a computational method …
networks are key challenges in systems biology. We developed a computational method …
[HTML][HTML] Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism
Genetic studies have identified dozens of autism spectrum disorder (ASD) susceptibility
genes, raising two critical questions:(1) do these genetic loci converge on specific biological …
genes, raising two critical questions:(1) do these genetic loci converge on specific biological …
[HTML][HTML] A systems-level analysis of the peripheral nerve intrinsic axonal growth program
V Chandran, G Coppola, H Nawabi, T Omura… - Neuron, 2016 - cell.com
The regenerative capacity of the injured CNS in adult mammals is severely limited, yet
axons in the peripheral nervous system (PNS) regrow, albeit to a limited extent, after injury …
axons in the peripheral nervous system (PNS) regrow, albeit to a limited extent, after injury …
[HTML][HTML] Latent enhancers activated by stimulation in differentiated cells
According to current models, once the cell has reached terminal differentiation, the enhancer
repertoire is completely established and maintained by cooperatively acting lineage-specific …
repertoire is completely established and maintained by cooperatively acting lineage-specific …
[HTML][HTML] Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells
Naive embryonic stem cells hold great promise for research and therapeutics as they have
broad and robust developmental potential. While such cells are readily derived from mouse …
broad and robust developmental potential. While such cells are readily derived from mouse …
[HTML][HTML] The little skate genome and the evolutionary emergence of wing-like fins
F Marlétaz, E de la Calle-Mustienes, RD Acemel… - Nature, 2023 - nature.com
Skates are cartilaginous fish whose body plan features enlarged wing-like pectoral fins,
enabling them to thrive in benthic environments,. However, the molecular underpinnings of …
enabling them to thrive in benthic environments,. However, the molecular underpinnings of …