Estrogen influences the physiology of many target tissues in both women and men. The long-
term effects of estrogen are mediated predominantly by nuclear estrogen receptors (ERs) …

Abstract Activating transcription factor 3 (ATF3) gene encodes a member of the ATF family of
transcription factors and is induced by various stress signals. All members of this family …

Tau aggregation in neurofibrillary tangles (NFTs) is closely associated with
neurodegeneration and cognitive decline in Alzheimer's disease (AD). However, the …

Microglia have critical roles in neural development, homeostasis and neuroinflammation
and are increasingly implicated in age-related neurological dysfunction. Neurodegeneration …

Identifying master regulators of biological processes and mapping their downstream gene
networks are key challenges in systems biology. We developed a computational method …

Genetic studies have identified dozens of autism spectrum disorder (ASD) susceptibility
genes, raising two critical questions:(1) do these genetic loci converge on specific biological …

The regenerative capacity of the injured CNS in adult mammals is severely limited, yet
axons in the peripheral nervous system (PNS) regrow, albeit to a limited extent, after injury …

According to current models, once the cell has reached terminal differentiation, the enhancer
repertoire is completely established and maintained by cooperatively acting lineage-specific …

Naive embryonic stem cells hold great promise for research and therapeutics as they have
broad and robust developmental potential. While such cells are readily derived from mouse …

Skates are cartilaginous fish whose body plan features enlarged wing-like pectoral fins,
enabling them to thrive in benthic environments,. However, the molecular underpinnings of …