State‐of‐the‐art human adenovirus vectorology for therapeutic approaches

J Gao, K Mese, O Bunz, A Ehrhardt - FEBS letters, 2019 - Wiley Online Library
Human adenoviruses (Ads) have long been studied in the basic virology field and are
exploited as vectors for gene therapy, vaccination, and oncolytic therapy. Ads are usually …

Adenovirus receptors: implications for tropism, treatment and targeting

N Arnberg - Reviews in medical virology, 2009 - Wiley Online Library
Adenoviruses (Ads) are the most frequently used viral vectors in gene therapy and cancer
therapy. Obstacles to successful clinical application include accumulation of vector and …

The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis

EC Nilsson, RJ Storm, J Bauer, SMC Johansson… - Nature medicine, 2011 - nature.com
Abstract Adenovirus type 37 (Ad37) is a leading cause of epidemic keratoconjunctivitis
(EKC),, a severe and highly contagious ocular disease. Whereas most other adenoviruses …

Current status of cardiovascular gene therapy

TT Rissanen, S Ylä-Herttuala - Molecular Therapy, 2007 - cell.com
Gene transfer for the therapeutic modulation of cardiovascular diseases is an expanding
area of gene therapy. During the last decade several approaches have been designed for …

MicroRNAs as a therapeutic target for cardiovascular diseases

PK Mishra, N Tyagi, M Kumar… - Journal of cellular and …, 2009 - Wiley Online Library
• Introduction• Biogenesis of miRNAs and their regulatory mechanisms• MiRNAs in
cardiovascular diseases• MiRNAs in hypertrophy• MiRNAs in cardiac fibrosis• MiRNAs in …

Molecular evolution of human species D adenoviruses

CM Robinson, D Seto, MS Jones, DW Dyer… - Infection, Genetics and …, 2011 - Elsevier
Adenoviruses are medium-sized double stranded DNA viruses that infect vertebrates.
Human adenoviruses cause an array of diseases. Currently there are 56 human adenovirus …

The EuroBioBank Network: 10 years of hands-on experience of collaborative, transnational biobanking for rare diseases

M Mora, C Angelini, F Bignami, AM Bodin… - European Journal of …, 2015 - nature.com
The EuroBioBank (EBB) network (www. eurobiobank. org) is the first operating network of
biobanks in Europe to provide human DNA, cell and tissue samples as a service to the …

Human adenovirus 52 uses sialic acid-containing glycoproteins and the coxsackie and adenovirus receptor for binding to target cells

A Lenman, AM Liaci, Y Liu, C Årdahl, A Rajan… - PLoS …, 2015 - journals.plos.org
Most adenoviruses attach to host cells by means of the protruding fiber protein that binds to
host cells via the coxsackievirus and adenovirus receptor (CAR) protein. Human adenovirus …

Gene therapy: targeting the myocardium

AR Lyon, M Sato, RJ Hajjar, RJ Samulski, SE Harding - Heart, 2008 - heart.bmj.com
Effective clinical delivery of gene therapy to the heart requires understanding and design of
complex biological systems to deliver therapeutic gene expression. The development of …

The adenovirus vector platform: novel insights into rational vector design and lessons learned from the COVID-19 vaccine

E Sallard, W Zhang, M Aydin, K Schröer, A Ehrhardt - Viruses, 2023 - mdpi.com
The adenovirus vector platform remains one of the most efficient toolboxes for generation of
transfer vehicles used in gene therapy and virotherapy to treat tumors, as well as vaccines to …