▪ Abstract The MCM proteins are essential replication initiation factors originally identified as
proteins required for minichromosome maintenance in Saccharomyces cerevisiae. The best …

Replication of the two template strands at eukaryotic cell DNA replication forks is a highly
coordinated process that ensures accurate and efficient genome duplication. Biochemical …

In humoral defence, pathogens are cleared by antibodies acting as adaptor molecules: they
bind to antigen and trigger clearance mechanisms such as phagocytosis, antibody …

Replication protein A (RPA) is a heterotrimeric single-stranded DNA-binding protein that is
highly conserved in eukaryotes. RPA plays essential roles in many aspects of nucleic acid …

The mechanism of ribosome binding to eucaryotic mRNAs is not well understood, but it
requires the participation of eucaryotic initiation factors eIF-4A, eIF-4B, and eIF-4F and the …

▪ Abstract DNA primases are enzymes whose continual activity is required at the DNA
replication fork. They catalyze the synthesis of short RNA molecules used as primers for …

Three tandem repeats of a 13-mer in the AT-rich region are essential to the unique
replication origin of E. coli and of remotely related Enterobacteriaceae. These iterated …

Modulation of RNA structure is an essential step in many fundamental processes, including
RNA synthesis, splicing, replication, and translation. Recently, an increasing number of …

The replication of simian virus 40 (SV40) DNA is largely dependent upon cellular replication
proteins. To define these proteins we have made use of a cell-free system that is capable of …

RNA metabolism plays a central role in cell growth. It is essential to regulate RNA synthesis,
processing, stability and degradation. Conformational changes in RNA are key elements in …